Assessment of the Health Improvement of Obese Patients After Fecal Microbiota Transplantation (FMT)

Federal Research and Clinical Center of Physical-Chemical Medicine2 enrolled

Overview

Search for mechanisms of the effect of fecal microbiota transplantation on patients with obesity

1. To select recipients of fecal samples according to eligibility criteria; 2. To perform fecal microbiota transplantation for patients with obesity; 3. To analyze the efficacy of fecal microbiota transplantation for patients with obesity within six months after therapy.

Study Type

INTERVENTIONAL

Allocation

NON_RANDOMIZED

Purpose

TREATMENT

Masking

NONE

Enrollment

Conditions

Obesity; Familial

Interventions

Fecal microbiotaOTHER

Transplantation of fecal microbiota of healthy donor with normal body mass index

Eligibility

Sex: MALEMin age: 40 YearsMax age: 50 YearsHealthy volunteers:

Medical Language ↔ Plain English

Inclusion Criteria: * age of patients - from 18 to 75 years, both sexes; * patients with obesity (body mass index ≥40 * patient's informed consent to perform fecal microbiota transplantation Exclusion Criteria: * presence of a concomitant chronic infectious disease or malignancy * patients with a proven allergy to foods not excluded from the donor's diet * absence of the patient for one or more intermediate stages of the examination. * informed refusal to continue therapy

Locations (2)

Endocrinology Research Centre, Moscow

Moscow, Russia

Federal Research and Clinical Center of Physical-Chemical Medicine, Moscow (FRCC PCM)

Moscow, Russia

Outcomes

Primary Outcomes

Change in insulin sensitivity within FMT, 6 months after FMT]

participants will undergo euglycaemic glucose clamp study

Time frame: 6 months after FMT

Data from ClinicalTrials.gov

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