The Effect of Frailty and Other Geriatric Syndromes on the Prognosis of Elderly Patients With Acute Coronary Syndrome

Beijing Friendship Hospital1,000 enrolled

Overview

This is a prospective observational clinical trail which will recruit 1000-1500 participants over 65 years with frailty and acute coronary syndrome (ACS) in Beijing Friendship hospital. The investigators will conduct frailty assessment (FRAIL scale, CFS, SPPB), comorbidities, functional status (Barthel index, ADL, IADL), nutritional risk (MNA-SF), and then observe the clinical outcomes of elderly ACS participants with frailty. Then, the investigators will follow-up these participants separately in 1,3,6 and 12months, the anticipate follow-up time is 1 year. According to the follow-up results, investigators will evaluate the impact of frailty and other senile syndromes on the short-term and long-term prognosis of ACS, and develop a scoring system for the prognosis evaluation of elderly ACS participants.

Study Type

OBSERVATIONAL

Enrollment

1,000

Conditions

ACS Frail Elderly Syndrome Elderly Patient

Interventions

this is an observational study with none intervention

Eligibility

Sex: ALLMin age: 65 Years

Medical Language ↔ Plain English

Inclusion Criteria: * Elderly participants over 65 * Clinical diagnosis of acute coronary syndrome * Must be able to follow-up * Sign in the informed consent Exclusion Criteria: * Myocardial infarction caused by other acute disease * Mental disorders who cannot cooperate to complete the assessment * Severe liver dysfunction, kidney disease (CKD 5), end-stage malignant tumor * Totally disabled and bedridden

Outcomes

Primary Outcomes

Death

All-cause death and cardiac death events

Time frame: During hospitalization, assessed up to 2 months

Major Adverse Cardiac and Cerebrovascular events

Major Adverse Cardiac and Cerebrovascular events including heart failure, cardiac shock, malignant arrhythmia, myocardial infarction, revascularization, and cerebral infarction