Heart and Kidney Ketones Metabolism

Université de Sherbrooke10 enrolled

Overview

Participants will undergo 3 Positron Emission Tomography (PET) scans in 3 different conditions : 1. Fasting without exogenous ketone salt 2. Fasting with exogenous ketone salt supplement 3. Post-Prandial with exogenous ketone salt supplement.

This study will help to quantify heart and kidney ketone uptake with or without an exogenous ketone salt with or without food intake in middle-aged adults. Participants will have 3 different PET scan to perform : 1. Fasting without exogenous ketone salt 2. Fasting with exogenous ketone salt supplement 3. Post-Prandial with exogenous ketone salt supplement.

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

BASIC_SCIENCE

Masking

NONE

Enrollment

Conditions

Healthy

Interventions

Fasting with exogenous ketone salt supplementDIETARY_SUPPLEMENT

Participants will have to take 2 doses of supplement, one 75 minutes before the scan and one 30 minutes before the scan.

Post-Prandial with exogenous ketone salt supplementDIETARY_SUPPLEMENT

Participants will have to take 2 doses of supplement, one 75 minutes before the scan and one 30 minutes before the scan and they will have a liquid meal 20 minutes before the scan.

Eligibility

Sex: ALLMin age: 45 YearsMax age: 64 YearsHealthy volunteers:

Medical Language ↔ Plain English

Inclusion Criteria: * Aged between 45 and 64 * Generally Healthy * BMI between 18.5 and 27 Exclusion Criteria: * All drugs taken on a daily basis * Diabetes or pre-diabetes * Digestive dysfunction * Pregnancy or lactation * Allergy to the supplement * Participate in an intensive physical exercise training (more than three times a week) * Being on a ketogenic diet or consumption of ketogenic supplement. * More than 2 alcoholic beverages each day * Any clinically significant anomaly in the blood profile * Smoking * Claustrophobia * Being enrolled in another interventional research project or in a PET research project * Unable to lie dorsally supine for at least 60 minutes

Locations (1)

Rearsh Centre on Aging

Sherbrooke, Quebec, Canada

Outcomes

Primary Outcomes

11C-Acetoacetate Heart Ketone uptake

Heart ketone uptake measured by PET scan

Time frame: 60 minutes

11C-Acetoacetate Kidney ketone uptake

Kidney ketone uptake measured by PET scan

Time frame: 60 minutes

Cardiac Functions, telediastolic volume

telediastolic volume

Time frame: 60 minutes

Cardiac Functions, telesystolic volume

telesystolic volume

Time frame: 60 minutes

Cardiac functions, ejection fraction

Ejection fraction

Time frame: 60minutes

Secondary Outcomes

Plasma ketone

Plasma ketone concentration

Time frame: 60 minutes

Data from ClinicalTrials.gov

This platform is for informational purposes only and does not constitute medical advice. Always consult a qualified healthcare professional.