General anesthesia induces hemodynamic changes, notably a reduction of arterial blood pressure going up to 30%, that may impact cerebral perfusion and oxygenation.The purpose of this study is to assess the impact of anesthesia on the cerebral oxygenation, the perfusion of the brain (assessed with transcranial doppler), and the depth of anesthesia in children between 6 months and 5 years old during the induction of general anesthesia (induced with sevoflurane and/or IV agents). It is expected that the cerebral hemodynamic will be maintained despite systemic variations.
Study Type
OBSERVATIONAL
Enrollment
50
Children under general anesthesia for an elective surgery, aged between 6 months and 5 years old, ASA 1-2.
Sainte Justine Hospital
Montreal, Quebec, Canada
Changes in NIRS values during induction
Changes in cerebral Near infra-red spectrometry values
Time frame: baseline and 1 minute after intubation
Changes in cerebral velocity of the middle cerebral artery during induction
Time frame: baseline and 1 minute after intubation
Changes of Response Entropy (RE) value during induction
Time frame: baseline and 1 minute after intubation
Changes of State Entropy (SE) value during induction
Depth of anesthesia
Time frame: baseline and 1 minute after intubation
Changes in NIRS values after induction
Time frame: At 1 minute, 3 minutes after intubation and at the start of surgery
Change in cerebral velocity of the middle cerebral artery after induction
Time frame: At 1 minute, 3 minutes after intubation and at the start of surgery
Changes of arterial blood pressure during induction
Time frame: At baseline and 1 minute after intubation
Changes of Response Entropy (RE) values after induction
Time frame: At 1 minute, 3 minutes after intubation and at the start of surgery
Endtidal Co2 after induction
Time frame: 1 minute after intubation
Changes of State Entropy (SE) value after induction
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Time frame: At 1 minute, 3 minutes after intubation and at the start of surgery