The Role of Dietary Carbohydrate and Fat Availability in the Regulation of Hepatic Lipid Content

Hvidovre University Hospital12 enrolled

Overview

The purpose of this study is to investigate dietary compositions effect on liverfat measured by magnetic resonance imaging.

Overweight but otherwise healthy men will be included in the study which is a randomized diet intervention study in a cross over design. The study involves 2 intervention periods of 5 days each, during which the participant ingests two different types of experimental diet. Participants will in randomized order (determined by block randomization) ingest a diet with low carbohydrate and high fat content, and a diet with high carbohydrate and low fat content.

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

BASIC_SCIENCE

Masking

NONE

Enrollment

Conditions

NAFLD Overweight and Obesity Metabolic Syndrome Diabetes

Interventions

High Carb Low Fat DietOTHER

The participants will be randomized to a diet of low carb/ high fat og high carb/low fat

Low Carb High Fat DietOTHER

The participants will be randomized to a diet of low carb/ high fat og high carb/low fat

Eligibility

Sex: MALEMin age: 18 YearsMax age: 50 YearsHealthy volunteers:

Medical Language ↔ Plain English

Inclusion Criteria: * Healthy men being 18-50 years old. * Overweight (BMI 25-35) * Low to moderate physical activity level, defined as ≤ 1 weekly session of aerobic exercise. * Non-smokers * No use of medicine Exclusion Criteria: * Fasting blood glucose indicating overt diabetes (≥7 mmol/l) * HbA1C \>48 mmol/mol * Fasting plasma triacylglycerol indicating dyslipidemia (≥2.2 mmol/l) * FIB-4 score \>1.45 * Contraindications for MR-scan: abdominal height exceed limitations of the MR-scanner, pacemaker or other electronic device implanted, implanted metal devices, severe claustrophobia.

Locations (1)

Amalie London

Hvidovre, Denmark

Outcomes

Primary Outcomes

Liverfat

The effect of high-carbohydrate/low-fat vs low-carbohydrate/high-fat diet on change in MRS determined liver fat.

Time frame: (MRS Day -1 (before intervention starts), Day 5 (after diet intervention is completed)

Secondary Outcomes

Glycogen

effect of the low-carbohydrate/high-fat intake and high-carbohydrate/low-fat intake on hepatic glycogen content measured by 7T 13C-MRS

Time frame: (MRS Day -1 (before intervention starts), Day 5 (after diet intervention is completed)

fasting hepatic glucose output

measured by Ra of glucose= (infusion rate of 6,6 2H2-glucose)/TTR

Time frame: (Day 0 and Day 6 of the diet intervention)

fasting blood triacylglycerol concentration

Time frame: (Day 0 and Day 6 of the diet intervention)

Insulin clearance determined during steady state insulin infusion

Time frame: (Day 0 and Day 6 of the diet intervention)

Data from ClinicalTrials.gov

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