The Role of OCTA in Patients Affected by Beta Thalassemia

Federico II University82 enrolled

Overview

To investigate, using optical coherence tomography angiography (OCTA), the retinal and choriocapillaris vascular features in patients affected by Beta Thalassemia. Moreover we analyzed the structural retinal parameters (ganglion cell complex and retinal nerve fiber layer), using optical coherence tomography (OCT) in these patients

Beta Thalassemia is one of the most common genetic hemoglobinopathy characterized by a defective β globulin chain synthesis leading to hemolysis and ineffective erythropoiesis. The study investigated the changes in retinal and choriocapillaris vascular features using optical coherence tomography angiography, a novel and noninvasive diagnostic technique that allows a detailed analysis of retinal and choriocapillaris blood flow.

Study Type

OBSERVATIONAL

Enrollment

Conditions

Thalassemia

Interventions

Optical coherence tomography angiographyDIAGNOSTIC_TEST

Each subject underwent Optical coherence tomography angiography (a non-invasive, fast, diagnostic imaging technique)

Eligibility

Sex: ALLMin age: 35 YearsMax age: 50 YearsHealthy volunteers:

Medical Language ↔ Plain English

Inclusion Criteria: * age older than 35 years * diagnosis of Beta Thalassemia * absence of previous ocular surgery, congenital eye disease, high myopia (\>6 dioptres), actual or previous diagnosis of glaucoma, optic disc anomaly, macular or vitreoretinal diseases. * absence of significant lens opacities, low-quality OCT and OCT-A images. Exclusion Criteria: * age older than 50 years * absence of diagnosis of Beta Thalassemia * presence of previous ocular surgery, congenital eye disease, high myopia (\>6 dioptres), actual or previous diagnosis of glaucoma, optic disc anomaly, macular or vitreoretinal diseases. * presence of significant lens opacities, low-quality OCT and OCT-A images.

Locations (1)

University of Naples "Federico II"

Naples, Italy

Outcomes

Primary Outcomes

The measurements of retinal and choriocapillaris features in patients with Beta Thalassemia, using optical coherence tomography angiography.

The parameters analyzed by optical coherence tomography angiography were: retinal and choriocapillaris vessel density

Time frame: Four months

Secondary Outcomes

The measurements of retinal structural parameters in patients with Beta Thalassemia, using optical coherence tomography.

The parameters analyzed by optical coherence tomography were: ganglion cell complex and retinal nerve fiber layer

Time frame: Four months

Data from ClinicalTrials.gov

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