Lung Ultrasound Artefact Analysis for Exclusion of Acute Rejection in Lung Transplant Recipients

Mayo Clinic90 enrolled

Overview

This study is being done to study a safe and non-invasive way to diagnose lung rejection and infection.

Lung transplant recipients are at high risk for lung rejection and lung infection after transplant. This is diagnosed by performing lung bronchoscopies and lung biopsies. These procedures carry an increased risk for complications and are costly. This study is being done to study a safe and non-invasive way to diagnose lung rejection and infection.

Study Type

INTERVENTIONAL

Allocation

Purpose

DIAGNOSTIC

Masking

NONE

Enrollment

Conditions

Post-Lung Transplantation Bronchiectasis

Interventions

Lung ultrasoundDIAGNOSTIC_TEST

The lung ultrasound will be performed by a trained pulmonologist by gently pressing a probe to various areas of your chest. This is a non-invasive procedure and you should not feel any pain. The ultrasound will take less than 10 minutes.

Eligibility

Sex: ALLMin age: 18 YearsHealthy volunteers:

Medical Language ↔ Plain English

Inclusion Criteria: * Adult patients (\> 18 yrs) who had undergone single/double/heart-lung transplant * Asymptomatic * Normal spirometry defined as a FEV1 without significant drop from baseline (significant drop = \>10% decrease from baseline) * Clear chest radiograph over allograft Exclusion Criteria: * Patients who are unable to consent for the procedure * Patients with subcutaneous emphysema or other technical challenges that could interfere with satisfactory image acquisition- as deemed by the operator.

Locations (1)

Mayo Clinic in Florida

Jacksonville, Florida, United States

RECRUITING

Outcomes

Primary Outcomes

Establish predictive value of lung ultrasound

Determine if lung ultrasound provides the same diagnostic results as bronchoscopy and biopsy

Time frame: Month 0 to month 12

Data from ClinicalTrials.gov

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