Epithelial ovarian cancer (EOC) is the most lethal gynecological malignancy. PARP inhibitors(PARPi) are an important progress in EOC treatment. The available evidence suggests that BRCAmt or HRD-positive is an effective biological marker for PARPi. However, in our previous clinical observation, it was found that the tumor burden may be the potential clinical markers PARPi. We intend to develop a real-world study to confirm the potential clinical markers and explore new clinical markers for PARPi.
This study intends to conduct a systematic real-world study to observe the relationship between the clinical characteristics of EOC patients and the efficacy of PARPi based on our existing research foundation and stratified analyse these correlations by BRCA and HRD status.
Study Type
OBSERVATIONAL
Enrollment
60
Ovarian cancer patients with PARP inhibitors according to the NCCN guideline and their instructions.
Xiaoxiang Chen, MD,PhD
Nanjing, Jiangsu, China
RECRUITINGOverall Response Rate (ORR)
ORR is defined as the proportion of participants achieving complete response (CR) or partial response (PR) as assessed by RECIST1.1.
Time frame: Through study completion, an average of 1 year
Progression Free Survival (PFS)
PFS is defined as the time in months from the date of first study drug administration to the date of first documentation of progressive disease (PD) or death as assessed by RECIST1.1.
Time frame: Through study completion, an average of 1 year
Duration of Response (DOR)
DOR is defined as the time from the first date of response until the date of first documented progression.
Time frame: Through study completion, an average of 1 year
Disease Control Rate (DCR)
DCR is defined as the proportion of participants achieving complete response (CR), partial response (PR) or stable disease (SD) according to RECIST1.1.
Time frame: Through study completion, an average of 1 year
Adverse events (AEs)
Number of participants with treatment-related adverse events as assessed by CTCAE 5.0 to further describe safety and assess toxicities encountered with the use of the proposed treatment regimen in participants.
Time frame: Through study completion, an average of 1 year
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