Interplay of miRNA-146a and miRNA-126 in Chronic Periodontitis Patients With Coronary Artery Disease

Meenakshi Ammal Dental College and Hospital75 enrolled

Overview

The role of micro-RNAs in chronic periodontitis associated with CAD is still in an incipient stage needs to be explored further. The investigators attempt to quantify and compare the levels of micro-RNA 146a and micro-RNA 126 in subgingival as well as coronary plaque samples obtained from patients diagnosed with chronic periodontitis with and without coronary artery disease. Seventy-five participants were selected and grouped into 3 categories; 25 patients diagnosed with chronic periodontitis and coronary artery disease: CP + CAD group; 25 patients diagnosed with chronic periodontitis alone: CP group; and 25 systemically and periodontally healthy controls (HP). Demographic variables, periodontal parameters, cardiac parameters, blood pressure were obtained. miRNA-146a and miRNA126 levels were assessed in subgingival plaque (SP) samples from all the three groups. Within CP+CAD group, SP samples of CP+CADa were compared with coronary plaques samples (CP) of CP+CADb while the patient underwent CABG.

Study Type

OBSERVATIONAL

Enrollment

Conditions

Chronic Periodontitis Coronary Artery Disease miRNA

Eligibility

Sex: MALEMin age: 30 YearsMax age: 70 Years

Medical Language ↔ Plain English

Inclusion criteria: * Patients volunteering for the investigation. * Patients between the age group of 30-70 years * Presence of ≥ 15 natural teeth. Exclusion criteria: * Patients associated with systemic diseases such as lung disorders, renal disease, liver disease, type I, type II-diabetes mellitus, HIV infection, rheumatoid arthritis, allergy or any malignancy. * Under treatment with antibiotics, immunosuppressive drugs such as corticosteroids, within 6 months. * Pregnant women and female patients were excluded because of the altered oral flora due to hormonal changes * Smoking and other tobacco usage habits * Patients who underwent periodontal treatment within 6 months.

Locations (1)

Meenakshi Ammal Dental college

Chennai, Tamil Nadu, India

Outcomes

Primary Outcomes

micro-RNA 146-a expression in Chronic periodontitis patients with and without coronary heart disease.

microRNA 146-a expression was present in the chronic periodontitis subjects with coronary heart disease

Time frame: 10 months

Levels of micro-RNA 126 in chronic periodontitis patients with and without coronary heart disease

microRNA 126 expression was present in chronic periodontitis subjects with coronary heart disease

Time frame: 10 months

Data from ClinicalTrials.gov

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