Hypofractionated External-beam RadiOtherapy for Intact Cervical Cancer (HEROICC-Trial): A Feasibility Study

Inclusion Criteria: * Age 18 years or older * International Federation of Gynecology and Obstetrics (FIGO) IA or IB1 cervical cancers if not surgical candidates, but amenable to definitive chemoradiotherapy as proposed in this trial. * FIGO Stage IB2, IB3, IIA or IIB cervical cancers * FIGO stage IIIC1 cervical cancers are candidates but must meet all the following criteria: 1. largest node is less than 3 cm 2. less than 3 pathological nodes 3. No nodes located in the common iliac chain. 4. Cervical confined or with parametrial invasion * Histologically-confirmed invasive uterine cervical carcinoma of subtypes squamous cell, adenocarcinoma or adenosquamous cell * Candidate for definitive chemoradiotherapy to be delivered with weekly cisplatin * Brachytherapy candidate Exclusion Criteria: * FIGO stage IIIA, IIIB, IIIC2, IVA or IVB * FIGO stage IIIC1 with node greater than 3 cm, common iliac node or greater than 2 pathological nodes * Previous pelvic or abdominal radiotherapy * Patients requiring paraaortic nodal irradiation * Inflammatory bowel disease * Connective tissue disorder (eg. scleroderma, systemic lupus erythematous) * Neuroendocrine, glassy cell, small cell, adenoid cystic carcinoma, adenoid basal carcinoma, clear cell, serous, endometrioid, verrucous carcinoma, melanoma, and sarcoma histologies * Patient unable to undergo MR scan * Eastern Cooperative Oncology Group (ECOG) performance status greater than 3 * Not a cisplatin candidate