COVID-19 as a novel disease, different disease patterns were observed worldwide, and many treatment plans were tried. So, it is important to investigate the Egyptian clinical characteristics and different factors that determine the patient's 'outcome
Investigators will convey the Ain Shams University experience as the first university in Egypt to designate one of its hospitals (Ain Shams University Obour Hospital) for management of confirmed COVID19 cases. investigators will try to identify the characteristics of the disease as regards the clinical, laboratory and imaging abnormalities and to assess the outcome determinants. It is a retrospective observational cohort study at Ain Shams University Obour Hospital. All adult patients from both sexes with positive nucleic acid testing for severe adult respiratory syndrome Coronavirus (SARS-CoV-2)will be included. Clinical criteria, laboratory data, radiological findings, hospital course and patient outcome will be anonymously collected from records.
Study Type
OBSERVATIONAL
Enrollment
100
Complete blood count with differential leucocytic count. Absolute lymphocytic and neutrophilic count. Liver functions: Aspartate transaminase and Alanine transaminase . Renal functions: Blood urea nitrogen, serum Creatinine. HbA1C. C-reactive protein (quantitative). Serum ferritin level. D - dimer level (quantitative). Coagulation profile (Prothrombin time/ Partial thromboplastin time/ International normalized ratio). Troponin level. Arterial blood gases when needed.
Faculty of Medicine Ain Shams University Research Institute- Clinical Research Center
Cairo, Non-US, Egypt
RECRUITINGRecovery
Recovery defined as resolution of fever without the use of antipyretics, improvement of respiratory symptoms (e.g., cough, dyspnea) and no need for supplemental oxygen
Time frame: Until patient is discharged or up to 12 weeks whichever comes first
Mortality
All cause mortality
Time frame: Until patient is discharged or up to 12 weeks whichever comes first
Conversion of nucleic acid testing for SARS-CoV-2 from positive to negative.
Detected by Polymerase Chain Reaction (PCR) test for nasopharyngeal swab
Time frame: Until patient is discharged or up to 12 weeks whichever comes first
Radiological progression of the COVID 19 disease
detected by measuring the extent of pulmonary lesion in high resolution computed tomography (HRCT) of the chest
Time frame: Until patient is discharged or up to 12 weeks whichever comes first
Functional progression of the COVID 19 disease
increase oxygen demands detected by arterial blood gases analysis and/or pulse oximeter
Time frame: Until patient is discharged or up to 12 weeks whichever comes first
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