The purpose of this study is to investigate the impact of caffeine on myocardial oxygenation and other cardiovascular magnetic resonance parameters in healthy controls.
Caffeine is presumed to create a confounder with diagnostic imaging. The vasodilatory capacity is considered a key measure for the detection of significant coronary disease with stenosed epicardial arterial conduit vessels and overall microvascular function, including endothelial dysfunction. Twenty nine healthy controls will undergo a baseline cardiovascular magnetic resonance (CMR) exam. Afterwards, participants will consume coffee in the presence of study personnel. This will consist of 3 espresso shots, which will be consumed within 15 minutes. Approximately 2h after coffee consumption the CMR exam will be repeated. The goal will be to investigate the impact of caffeine on myocardial features. In particular the effect on the myocardial oxygenation response to vasodilating and vasoconstricting stimuli.
Study Type
INTERVENTIONAL
Allocation
NA
Purpose
OTHER
Masking
NONE
Enrollment
29
Consumption of 3 shots of espresso
Bern University Hospital, Inselspital
Bern, Switzerland
Difference in myocardial oxygenation responses
Percent (%) Measure of oxygenation-sensitive signal change measured by CMR
Time frame: Through study completion up to 5 hours, before and after caffeine
Difference in ejection fraction
Percent (%), measured by CMR
Time frame: Through study completion up to 5 hours, before and after caffeine
Difference in cardiac index
L/min/m2, measured by CMR
Time frame: Through study completion up to 5 hours, before and after caffeine
Difference in myocardial peak strain
Percent (%), a measure of systolic function (shortening and thickening) of the myocardium measured by CMR
Time frame: Through study completion up to 5 hours, before and after caffeine
Difference in myocardial time to peak strain
Milliseconds (ms), measured by CMR
Time frame: Through study completion up to 5 hours, before and after caffeine
Difference in myocardial strain rate
Change in strain over time (/second), measured by CMR
Time frame: Through study completion up to 5 hours, before and after caffeine
Difference in myocardial parametric mapping
Milliseconds (ms), measured by CMR
Time frame: Through study completion up to 5 hours, before and after caffeine
Difference in 4D blood flow
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Percent, measured by CMR
Time frame: Through study completion up to 5 hours, before and after caffeine
Difference in rate pressure product
Blood pressure \* heart rate
Time frame: Through study completion up to 5 hours, before and after caffeine