NCT04585867 - Liposomal Bupivacaine vs Bupivacaine for Pain Control After Sternotomy | Crick

Overview

Researchers hope to learn whether giving the longer-acting local anesthetic liposomal bupivacaine prior to closing the sternum is more effective in managing pain following sternotomy, than in patients who received standard bupivacaine before sternal closure. Researchers will measure this based on how much IV pain medication is used, rates on confusion, and time to remove the breathing tube.

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

TREATMENT

Masking

TRIPLE

Enrollment

80

Conditions

Pain Management Sternotomy

Interventions

ExparelDRUG

The injections will be performed under direct guidance by the cardiac surgeon at bilateral sternal-costal interspaces 1.5 cm lateral the sternal boarder at levels 2-6 in divided doses (2 ml/injection) just before the closure of the sternum near the end of the surgical procedure. The final 20 ml will be injected into the skin incision after closure

BupivacaineDRUG

The injections will be performed under direct guidance by the cardiac surgeon at bilateral sternal-costal interspaces 1.5 cm lateral the sternal boarder at levels 2-6 in divided doses (2 ml/injection) just before the closure of the sternum near the end of the surgical procedure. The final 20 ml will be injected into the skin incision after closure

Eligibility

Sex: ALLMin age: 18 Years

Medical Language ↔ Plain English

Inclusion Criteria: * Adults over the age of 18 who present for elective open heart surgery that requires a sternotomy. Exclusion Criteria: * Urgent and emergency procedures, * preexisting sternal infections, * prior sternotomy, * preexisting pain syndromes, * current chronic home opioid use, * anterior rib or sternal masses, * allergy to any of the components of liposomal bupivacaine and plain bupivacaine.

Locations (1)

University of Kansas Medical Center

Kansas City, Kansas, United States

RECRUITING