Effect of Corticosteroid Treatment on Prognosis in ARDS Secondary to Covid-19

Central Hospital, Nancy, France200 enrolled

Overview

Study conducted on hospitalized patient in critical ill units in Nancy and Metz to evaluate if early corticosteroid treatment in first seven days after admission improve patients outcome in Acute Respiratory Distress Syndrome secondary to Covid-19 compared to later corticosteroid therapy or no treatment. Also comparison of acquired infection with or without corticosteroid treatment during hospitalisation.

Study Type

OBSERVATIONAL

Enrollment

200

Conditions

Acute Respiratory Distress Syndrome Secondary to Covid-19

Interventions

Corticosteroids and DerivativesDRUG

Any systemic corticosteroid treatment administrated during ICU stay

Eligibility

Sex: ALLMin age: 18 Years

Medical Language ↔ Plain English

Inclusion Criteria: * ICU hospitalized with acute respiratory distress syndrome secondary to Sars-Cov-2 infection diagnosed by PCR test * Hospitalized from 01/03/2020 to 30/04/2020 Exclusion Criteria: * Mechanical ventilation more than 48 hours at admission * Transfert to another ICU during stay for bed management * Corticosteroid treatment at admission

Locations (1)

Hopital Central, Service de Reanimation Medicale

Nancy, France

Outcomes

Primary Outcomes

Mortality in ICU

Mortality rates in ICU in each group

Time frame: within ICU stay, on average 15 days

Secondary Outcomes

Mortality d28

mortality at day 28 after ICU admission

Time frame: 28 days

acquired infections incidence

cumulative incidence of infection acquired during ICU stay

Time frame: 28 days

antibiotics duration

number of treatment days with antibiotics during ICU stay

Time frame: 28 days

mechanical ventilation duration

number of days of treatment by mechanical ventilation during ICU stay

Time frame: 28 days

Data from ClinicalTrials.gov

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