Clinical Trial of Selegiline Plus Docetaxel for the Treatment of Metastatic, Castrate-resistant Prostate Adenocarcinoma

Inclusion Criteria: 1. Age 18 years or older male patients, 2. Histologically or cytologically confirmed prostate adenocarcinoma 3. Radiologically confirmed metastatic disease, 4. Eligibility to receive oral therapy, 5. Suitable for docetaxel therapy, 6. Patients with castration-resistant prostate carcinoma who eligible to first-line docetaxel therapy or patients with castration-resistant prostate cancer who progressed after second-generation hormone therapy (abiraterone or enzalutamide) with pre-chemotherapy indication and eligible to second-line docetaxel therapy 7. At least 4 weeks has elapsed between the last antiandrogenic therapy and the inclusion (at least 6 weeks in case of bicalutamide), 8. Planned docetaxel treatment, 9. Eastern Cooperative Oncology Group (ECOG) performance status: ≤ 2, 10. Estimated life expectancy of more than 12 weeks, 11. Adequate analgesic therapy as required; 12. Patients must be able to follow the diet and medical instructions, 13. Use of effective contraception in men of childbearing age, 14. Provision of signed, written information consent Exclusion Criteria: 1. De novo metastatic patients who needs immediate docetaxel therapy; 2. Within 4 weeks prior to randomisation, the patient has received other study medication or failed to recover from any adverse events caused from a previously administered study drug 3. ≥ Grade 2 anticancer therapy-related toxicity (except alopecia), 4. Has had radiotherapy or immunotherapy within 4 weeks prior to treatment, 5. Has had a surgery within 4 weeks prior to treatment, 6. Known or suspected brain metastasis (stable patients with locally treated, asymptomatic brain metastases are not excluded), 7. Inadequate laboratory function: 1. Absolute neutrophil count \<1.5 x 109 /L (1,500 per mm3), 2. Platelet count \< 100 x 109 /L (100 000 per mm3), 3. Hemoglobin ≤9.0 g/dL, 4. Serum bilirubin \> ULN, 5. AST or ALT i.\>2.5 x ULN in patient without liver metastases, ii.\>5x ULN in patients with liver metastases. 8. Cardiological status: 1. Uncontrolled hypertension (BP ≥ 150/95 with hypertension treatment) 2. Heart failure (NYHA III or higher), 3. Current or former diagnosis of cardiomyopathy, 4. LVEF ≤ 50%, 5. Atrial fibrillation with \>100bpm pulse, 6. Unstable ischemic heart disease (myocardial infarction within 6 months or angina that require more than one nitrate therapy each week). 9. Other uncontrolled or severe systemic disease, active infection, hepatitis B, hepatitis C, HIV, 10. Uncontrolled seizure disorder, 11. Active gastric and duodenal ulcers, 12. Recurrent nausea and vomiting, chronic gastrointestinal disease or intestinal resection that prevents proper absorption, 13. Severe psychiatric illness (including but not limited to manic psychiatric disorder, schizophrenia, bipolar disorder, major depression requiring hospitalization) or social disturbance that limits eligibility for examination, 14. History of other malignancy within the last 5 years (except properly treated basalioma or squamous cell carcinoma of the skin and in situ carcinoma), 15. History of allergic reaction to phenelzine, selegiline or other monoamine oxidase inhibitors (MAOIs) biological agents or similar chemical ingredients, 16. History of allergic reaction to docetaxel therapy or its ingredients, 17. Significant peripheral neuropathy (≥ Grade 2), 18. Selegiline is contra-indicated for concomitant use with: 1. Certain narcotic analgesics (eg. pethidine), 2. Drugs that enhance the sympathetic nervous system, 3. Other MAO inhibitors, 4. Drugs similar to MAO inhibitors, 5. Selective serotonin reuptake inhibitors (SSRIs) or serotonin norepinephrine reuptake inhibitors (SNRIs), 6. Tricyclic antidepressants.