ST-Segment Resolution as a Marker for Myocardial Scar in ST-Segment Elevation Myocardial Infarction

Chongqing Medical University42 enrolled

Overview

Clinical studies found that poor ST-segment resolution (STR) in electrocardiogram (ECG) occurred in major adverse cardiovascular events (MACE), arrhythmia and heart failure was significantly higher . In clinical work, in patients have poor ST-segment decline, the investigators found by CMR-LGE the corresponding myocardium become thinner and other signs of myocardial scar. The investigators aimed to establish whether poor ST-segment resolution in ECG, as well as CMR-LGE, could detect the presence of myocardial scar in early STEMI patients. In order to provide convenient, cheap and widely used test method for patients who cannot tolerate CMR-LGE. 42 STEMI patients with single-branch coronary artery stenosis or occlusion were enrolled. ST-segment elevations were measured on the baseline and 24 hours after PCI. The study population was divided into two groups by late gadolinium enhanced cardiac magnetic resonance (LGE- CMR), with transmural myocardial scar (\>75%) or non-transmural myocardial scar (\<75%).

Study Type

OBSERVATIONAL

Enrollment

Conditions

Cardiovascular Diseases

Interventions

ST-segment resolution <40.15%DIAGNOSTIC_TEST

Forty-two STEMI patients with single-branch coronary artery stenosis or occlusion were enrolled. ST-segment elevations were measured at emergency admission and at 24 h after PCI. Late gadolinium-enhanced cardiac magnetic resonance imaging (CMR-LGE) was performed 7 days after PCI to evaluate myocardial scars.

Eligibility

Sex: ALLMin age: 30 YearsMax age: 80 Years

Medical Language ↔ Plain English

Inclusion Criteria: 1. Single-branch coronary artery stenosis or occlusion 2. Restoration of coronary perfusion to TIMI flow grade 3 after PCI Exclusion Criteria: 1. A prior history of the acute coronary syndrome 2. Coronary revascularization 3. Severe chronic kidney disease 4. Intracardiac pacing leads or other implants precluding CMR-LGE 5. Hemodynamic instability 6. Known claustrophobia

Outcomes

Primary Outcomes

ST-segment resolution<40.15%

CMR-LGE was performed to evaluate myocardial scars.

Time frame: 1) Emergency admission: ST-segment elevations were measured. 2) 24 hours after PCI: ST-segment elevations were measured. 3) 7 days after PCI: CMR-LGE was performed.

ST-segment resolution>40.15%