A Study to Assess Safety and Immunogenicity of Conserved Mosaic HIV-1 Vaccines

Inclusion Criteria: * Healthy adult aged 18-65 years * Able and willing (in the Investigator's opinion) to comply with all study requirements * Willing to allow the investigators to discuss the volunteer's medical history with their GP * Women of child-bearing potential agree to practice continuous effective contraception during the study and test negative for pregnancy on the day(s) of screening and vaccination * For sexually active men, willingness to use barrier methods for the purposes of contraception from screening until 4 months after the last vaccination * Agreement to refrain from blood donation during the course of the study * In the opinion of the Investigators, the volunteer has understood the information provided Written informed consent must be given before any study-related procedures are performed * Willing to undergo HCV, HBV, syphilis and HIV testing and counselling and receive test results Exclusion Criteria: * Confirmed HIV-1 or HIV-2 infection * Participation in another research study involving receipt of an investigational product in the 30 days preceding enrolment, or planned use during the study period * Prior receipt of a recombinant simian adenoviral vaccine prior to enrolment * Planned receipt of another adenoviral vectored vaccine within 90 days after the vaccination with the ChAdOx1.tHIVconsv1 IMP * Receipt of any investigational HIV-1/2 vaccine * Receipt of live attenuated vaccine within the previous 60 days or planned receipt within 60 days after vaccination with the IMP * Receipt of other vaccine, including influenza vaccine, within the previous 14 days or planned receipt within 14 days after vaccination with the IMP * Administration of immunoglobulins and/or any blood products within the three months preceding the planned administration of the vaccine candidate * Any confirmed or suspected immunosuppressive or immunodeficient state, including HIV-1/2 infection; asplenia; recurrent, severe infections and chronic (more than 14 days) immunosuppressant medication within the past 6 months (inhaled and topical steroids are allowed) * History of allergic disease or reactions likely to be exacerbated by any component of the vaccine * Any history of hereditary angioedema, acquired angioedema, or idiopathic angioedema. * Any history of anaphylaxis in relation to vaccination * Pregnancy, lactation or willingness/intention to become pregnant during the study * History of cancer (except basal cell carcinoma of the skin) * History of serious psychiatric condition likely to affect participation in the study * Bleeding disorder (eg. Factor deficiency, coagulopathy or platelet disorder), or prior history of significant bleeding or bruising following IM injections or venepuncture * Any other serious chronic illness requiring hospital specialist supervision * Suspected or known current alcohol abuse as defined by an alcohol intake of greater than 42 units every week * Suspected or known injecting drug abuse in the 5 years preceding enrolment * Reported high-risk behaviour for HIV-1/2 infection. High-risk behaviour for HIV-1/2 infection is defined as follows. Within the previous 12 months the volunteer has: * Had unprotected vaginal or anal sex with a person infected with HIV and not taking effective treatment, injecting drug users or casual partners (i.e., no continuing, established relationship) * Engaged in sex work for money or drugs * Used injection drugs * Acquired one of the following sexually transmitted infection: chlamydia, gonorrhea and syphilis. * Seropositive for hepatitis B surface antigen (HBsAg) * Seropositive for hepatitis C virus (antibodies to HCV) * Untreated Syphilis: Treponemal IgG/IgM and positive RPR/TPPA AND no documentation of adequate treatment * Any other significant disease, disorder or finding which may significantly increase the risk to the volunteer because of participation in the study, affect the ability of the volunteer to participate in the study or impair interpretation of the study data