Recent research has reported that the maple leaf extract exhibits anti-aging effects by inhibiting elastase activity, thereby preventing the breakdown of elastin and interfering with the formation of wrinkles. Red maple leaf extract contains phenolic compounds known as glucitol-core-containing gallotannins (GCGs) which help reduce the appearance of wrinkles and may decrease skin inflammation, dark spots and pigmentation. The objective of this study is to examine the effects of topical Maplifa on the cosmetic appearance of facial lines, redness and skin tone.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
QUADRUPLE
Enrollment
19
1% red maple leaf extract is combined in a cream base
5% red maple leaf extract is combined in a cream base
vehicle cream base only
Integrative Skin Science and Research
Sacramento, California, United States
Pigmentation on SkinColorCatch
Assessment of pigmentation based on melanin measurement on SkinColorCatch (arbitrary units set by technology)
Time frame: At 4 weeks (end of study)
Clinical grading of Hyperpigmentation
Assessment of hyperpigmentation based on clinical grading (categories 0-5) by blinded evaluator
Time frame: At 4 weeks (end of study)
Erythema on SkinColorCatch
Assessment of erythema based on SkinColorCatch (arbitrary units set by technology)
Time frame: At 4 weeks (end of study)
Clinical grading of Erythema
Assessment of erythema based on clinical grading (categories 0-5) by blinded evaluator
Time frame: At 4 weeks (end of study)
Centrofacial redness
Image-based analysis of redness \[Skinmap level Degree of Intensity (%) on BTBP Clarity Research 3D System\]
Time frame: At 4 weeks (end of study)
Appearance of wrinkles
Image-based analysis of wrinkles (Average severity - unitless on BTBP Clarity Research 3D System)
Time frame: At 4 weeks (end of study)
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