Catch me if You Can - the Individual Relationship Between Potential Ablation Targets From CARTOFINDER and Myocardial Fibrosis

Heart and Diabetes Center North-Rhine Westfalia20 enrolled

Overview

Single center observational study to compare the relationship between atrial fibrosis and potential ablation targets from CARTOFINDER.

A total number of 30 patients will undergo catheter Ablation for persistent AF. Pre-procedural cardiac MRI will be performed with late-gadolinium enhancement to visualize the individual amount and distribution of fibrosis in the right and left atrium. CARTOFINDER-guided mapping will be performed during the ablation procedure followed by AF ablation. The individual relationship between atrial fibrosis and potential ablation targets will be accessed.

Study Type

OBSERVATIONAL

Enrollment

Conditions

Atrial Fibrillation

Eligibility

Sex: ALLMin age: 18 Years

Medical Language ↔ Plain English

Inclusion Criteria: 1. Patients undergoing their 1st AF ablation procedure for persistent atrial fibrillation (AF) as per recent Heart Rhythm Society (HRS) consensus document 2. Able to understand and willing to sign the Informed Consent Form. 3. Age ≥18 years. Exclusion Criteria: 1. Contraindication for DE-MRI with a full dose of Gadolinium-based contrast agent. 2. Previous left atrial ablation or surgical procedure 3. Renal failure with CrCl \<60 ml/min 4. Women currently pregnant, breastfeeding, or of childbearing age not currently taking or not willing to use a reliable form of contraception 5. Mental or physical inability to take part in the study 6. Uncontrolled hypertension 7. Morbid obesity (BMI \> 35), or inability to be placed in MRI due to body mass.

Locations (1)

Herz- und Diabeteszentrum NRW, Ruhr-Universität Bochum

Bad Oeynhausen, Germany

Outcomes

Primary Outcomes

AF recurrence

recurrence of atrial fibrillation after catheter ablation

Time frame: 12 months

Data from ClinicalTrials.gov

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