Receptor Occupancy of LB-102 Using Positron Emission Tomography (PET) in Healthy Volunteers

Inclusion Criteria: Body Mass Index (BMI) ≥ 18 and ≤ 30 kg/m2 at screening visit. Competent to provide informed consent. Subjects must be in good general health as determined by medical history and physical examination with no clinically significant medical findings and no history of significant medical disease (e.g., cardiovascular, pulmonary, renal, etc.) or acute condition with the past 30 days, as determined by the study investigators. Have normal clinical laboratory test results and ECG, which are not considered to be clinically significant by the Investigator. Exclusion Criteria: 1. Are pregnant or lactating. 2. Have a history or presence of significant cardiovascular, respiratory, hepatic, renal, gastrointestinal, endocrine, neurological or psychological/psychiatric disorders which, in the opinion of the Investigator, increases the risk of the study drug or may confound the interpretation of study measures. 3. Clinically significant abnormal findings on physical examination or vital signs as determined by Investigator. 4. Individuals with pacemakers, aneurysm clips, shrapnel, or other restricted implanted metallic devices will be excluded from study. All subjects complete the standard MRI screening questionnaire prior to MRI. 5. History or presence of psychiatric or neurological disease or condition, as determined by the Investigator. 6. History of seizures. 7. Subject with any history or current evidence of suicidal behavior. 8. Unwilling to complete any planned study assessments. 9. Have a history of blood donation in excess of 500 mL of blood within 30 days prior to Screening. 10. Have received treatment with an investigational drug or device within 30 days prior to Screening. 11. Have a positive test for Human Immunodeficiency Virus (HIV) antibodies 1 and 2, Hepatitis B Surface Antigen (HBsAg) or Hepatitis C Virus (HCV) antibody. 12. Any subject who is known to be allergic to the study drug or any components of the study drug. 13. The subject has a fasting blood glucose ≥ 126 mg/dL or hemoglobin A1c (HbA1c) ≥ 6.5% at Screening. 14. The subject has a history of QT prolongation or dysrhythmia or a family history of prolonged QT interval or sudden death. 15. Clinically significant abnormal finding on ECG (electrocardiogram) and/or evidence of any of the following cardiac conduction abnormalities at Screening: 1. Heart rate \< 40 bpm and \> 100 bpm (based on the ECG reading) 2. QTcF interval \> 450 msec for males and females 3. PR interval ≥ 200 msec 4. Intraventricular conduction delay with QRS duration \> 120 msec 5. Evidence of second- or third-degree atrioventricular block (AVB) 6. Electrocardiographic evidence of complete left bundle branch block (LBBB), complete right bundle branch block (RBBB), or incomplete LBBB