Characterization of BAM8-22 as a New Surrogate Model of Non-histaminergic Itch

Aalborg University24 enrolled

Overview

With this experiment, the experimenter wish to asses if substance BAM8-22 (Bovine Adrenal Medulla) induce non-histaminergic itch.

With this experiment, the experimenter wish to establish if the substance BAM8-22 (Bovine Adrenal Medulla) induce a non-histaminergic itch by using the antihistamine Doxepin. The experimenter will also compare itch and the response to antihistamine of BAM8-22, histamine and cowhage.

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

BASIC_SCIENCE

Masking

SINGLE

Enrollment

Conditions

Itch

Interventions

BAM8-22DRUG

Bovine Adrenal Medulla will be applied to 2 previously determined area on the volar forearm (one alone and one in combination with doxepin)

HistamineDRUG

histamine will be applied to 2 previously determined area on the volar forearm (one alone and one in combination with doxepin)

Cowhage (Mucuna Pruriens)DRUG

cowhage spicules will be applied to 2 previously determined area on the volar forearm (one alone and one in combination with doxepin)

Eligibility

Sex: ALLMin age: 18 YearsMax age: 60 YearsHealthy volunteers:

Medical Language ↔ Plain English

Inclusion Criteria: * Healthy men and women * 18-60 years * Speak and understand English Exclusion Criteria: * Pregnancy or lactation * Drug addiction defined as any use of cannabis, opioids or other drugs * Previous or current history of neurological, dermatological, immunological musculoskeletal, cardiac disorder or mental illnesses that may affect the results (e.g. neuropathy, muscular pain in the upper extremities, etc.) * Moles, wounds, scars or tattoos in the area to be treated or tested * Lack of ability to cooperate • * Current use of medications that may affect the trial such as antihistamines and pain killers. * Skin diseases * Consumption of alcohol or painkillers 24 hours before the study days and between these - Acute or chronic pain • * Participation in other trials within 1 week of study entry (4 weeks in the case of pharmaceutical trials)

Locations (1)

Aalborg University

Aalborg, Denmark