The Safety, Tolerability, and Pharmacokinetics Study of HEC113995 PA•H2O Tablets in Healthy Subjects

Inclusion Criteria: * 1\. Subjects who are willing and are able to provide a written informed consent to participate in the study. * 2\. Without Plan for pregnancy or pregnant within 3 months after enrollment throughout the trial. * 3\. Subjects aged between 18 and 45 (both inclusive) years old. * 4\. Healthy volunteers has a body weight ≥50 kg (for male) or ≥ 45kg (for female) and body mass index ≥18 and ≤28 kg/m2 at screening. * 5\. Subjects, who are healthy, as having no clinically significant abnormalities in vital signs, physical examination, clinical laboratory test results, Chest X-ray and 12-lead electrocardiogram (ECG). Exclusion Criteria: * 1.Subjects with serum creatinine, ALT and AST levels ≥1.5 times of the upper limit of normal value at screening. * 2.Subjects with a positive serology for human immunodeficiency virus (HIV) antibodies, hepatitis B surface antigen (HBsAg), hepatitis C virus (HCV) antibodies and/or TP antibodies at screening. * 3\. Subjects with history of digestive system,urinary system, liver,central nervous system, blood system, endocrine system,respiratory system,immune system,cardiovascular system,and/or malignant tumor or others medical conditions (such as history of mental illness, etc.) that are not suitable for clinical trial participation;Subjects with history of epilepsy, bipolar disorder/mania, high intraocular pressure, or acute angular-closure glaucoma. * 4\. Known allergic reactions or hypersensitivity to any excipient of the drug formulation(s)# anaphylaxis physique. * 5\. Use of any prescription or non-prescription medications within 14 days prior to initial dosing#Use of any medications known to inhibit or induce cytochrome P enzyme drug metabolism within 28 days prior to initial dosing. * 6\. Consume foods or beverages containing caffeine, xanthine, alcohol, and grapefruit within 48 hours prior to initial dosing. * 7\. Positive results from urine drug screen test. * 8\. History of alcoholism or drink regularly within 3 months prior to the study(defined as Alcohol consumption of \> 21 units/week), or positive results from alcohol breath test. * 9.Regular smoking of more than 10 cigarettes per day within 3 months before administration of study drug, or inability to refrain from smoking during the course of the study. * 10\. Donate blood or lose blood 400 mL or more within 1 month prior to initial dosing. * 11\. Subjects who plan to receive or have had organ transplants. * 12\. Subjects who participated in another clinical trial within 3 months prior to initial dosing. * 13\. Any other condition with in the opinion of the investigator would render the patient unsuitable for inclusion in the study.