On Probiotic, Dental Caries, and Orthodontic Patients

Inclusion Criteria: * Subjects undergoing bimaxillary fixed orthodontic treatment * Number of S. mutans counts (\>10.000 CFU/ml) * Permanent dentition * 3-12 months into the treatment (study from Sweden by Andrea) * Medically healthy * Not taking any medication * Ability to understand the nature of the study and sign the consent form Exclusion Criteria: * Cleft lip and palate patients as well as handicapped and patients with mental impairments * Systemic diseases or conditions that could interfere with our study (diabetes, immunosuppression diseases, pregnancy or ongoing therapy). * History of probiotics/anti-inflammatory drugs taken during the last 4 weeks prior to baseline examination * Local or general antimicrobial substances taken during the last 4 prior weeks prior to baseline examination * Habitual consumers of xylitol chewing gums * No active or untreated carious lesions and reported daily tooth brushing habit using fluoridated toothpaste