Aim of study Compare the success rate of misoprostol with versus without letrozole as a pretreatment for medical termination of pregnancy during the first trimester. Hypothesis: Letrozole value as a pre-treatment medication for misoprostol in induction of abortion during the first trimester. Research question: Will letrozole- misoprostol protocol give better results than misoprostol- alone protocol in induction of abortion during the first trimester?
Aim of the Work Compare the success rate of misoprostol with versus without letrozole as a pretreatment for medical termination of pregnancy during the first trimester. Hypothesis: Letrozole value as a pre-treatment medication for misoprostol in induction of abortion during the first trimester. Research question: Will letrozole- misoprostol protocol give better results than misoprostol- alone protocol in induction of abortion during the first trimester? Primary outcome: Complete abortion (complete expulsion of products of conception with no need for curettage) within one week from the first dose of misoprostol. Secondary outcome: • Curettage (surgical evacuation of the products of conception) * Incomplete abortion (retained products of conception). * Considerable bleeding that necessitates immediate evacuation.
Study Type
OBSERVATIONAL
Enrollment
320
Letrozole give pretreatment of abortion by misoprostol
Give placebo pretreatment of abortion by misoprostol
Dalia Mohammed Al Sayed Zaki
Zagazig, Sharqia Province, Egypt
Complete abortion
Complete abortion (complete expulsion of products of conception with no need for curettage) within one week from the first dose of misoprostol.
Time frame: 1week
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