Submandibular Gland Stem Cell Transplantation

Inclusion Criteria: * Squamous cell carcinoma (SCC) originating from the mucosa of the oral cavity; * Primary resection of tumour including an electively or therapeutic ipsilateral neck dissection (at least levels Ib to III, including the submandibular gland). * Postoperative radiotherapy or chemoradiation, including prophylactic or therapeutic irradiation of the contralateral side of the neck (where the remaining submandibular gland is), including at least levels Ib to IV), next to irradiation of the tumour bed and ipsilateral neck (current standard); * Age ≥ 18 years; * WHO performance 0-2; * Written informed consent; Exclusion Criteria: * Primary (definitive) radiotherapy, with or without systemic treatment; * Previous radiotherapy of the head and neck region (re-irradiation); * Positive microbiological screening for Human Immunodeficiency Virus type 1 and 2, hepatitis B and C virus and Treponema pallidum. * Presence of systemic disease known to affect salivary gland functioning (e.g., Sjögren's syndrome); * Known allergy to mice and gentamicin * History within the past five years of malignancies other than: * basal or squamous cell carcinoma of the skin * in situ carcinoma of the cervix; * Females who are pregnant or lactating at entry.