Weight-Adjusted Dosing of 3-OHB in Patients With Chronic Heart Failure

University of Aarhus8 enrolled

Overview

We aim to investigate the hemodynamic effects of weight-adjusted dosing of ketone monoester en patients with chronic heart failure.

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

TREATMENT

Masking

DOUBLE

Enrollment

Conditions

Heart Failure Ketosis

Interventions

KetoneAid KE4 Pro MonoesterDIETARY_SUPPLEMENT

A dietary supplement containing ketone monoester.

Science in Sport Go EnegyDIETARY_SUPPLEMENT

Dosis isocaloric to the KetoneAid Arm

Eligibility

Sex: ALLMin age: 18 Years

Medical Language ↔ Plain English

Inclusion criteria: Chronic HF: NYHA class II-III, left ventricular ejection fraction (LVEF) \<40% Exclusion Criteria: Diabetes or HbA1c \>48 mmol/mol, significant cardiac valve disease, severe stable angina pectoris, severe comorbidity as judged by the investigator, inability to give informed consent

Locations (1)

Aarhus University Hospital

Aarhus, Denmark

RECRUITING

Outcomes

Primary Outcomes

Cardiac Output (L/min)

Change in Cardiac output measured by Swann-Ganz Catherization during study period,

Time frame: 3 hours - Area under the curve

Secondary Outcomes

Left Ventricular Ejection Fraction

Change in LVEF measured by echocardiography during study periode

Time frame: 3 hours - Area under the curve

Blood Ketones

Change in blood Ketones measured by venous blood samples

Time frame: 3 hours

Blood pH

Change in venous blood pH during the study period

Time frame: 3 hours

Central Contacts

Kristian H Christensen, MD

CONTACT

+4578452029 krstchri@rm.dk

Henrik S Wiggers, DMsci

CONTACT

Data from ClinicalTrials.gov

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