MPI Predicts Outcome of CRC Elderly Patients (MPI=MULTIDIMENSIONAL PROGNOSTIC INDEX; CRC=COLORECTAL CANCER)

Azienda Socio Sanitaria Territoriale degli Spedali Civili di Brescia104 enrolled

Overview

Patients aged ≥75 year scheduled for CRC surgery were studied (104 cases) and variables associated with major postoperative complications / mortality were evaluated. The importance of this report is that MPI-score resulted strongly associated with major complications and it was a primary component of an individual prediction model.

Patients aged ≥75 year scheduled for CRC surgery were studied (104 cases) and variables associated with major postoperative complications / mortality were evaluated. The MPI (multidimensional prognostic index)-score resulted strongly associated with major complications. also, it was a primary component of an individual prediction model (LASSO model).

Study Type

OBSERVATIONAL

Enrollment

104

Conditions

Colorectal Cancer Fragility Elderly

Interventions

surgeryPROCEDURE

colectomy

Eligibility

Sex: ALLMin age: 75 Years

Medical Language ↔ Plain English

Inclusion Criteria: All CRC patients aged ≥75 years, who were scheduled for elective surgery and able to express their consent to treatment, were considered. Exclusion Criteria: emergency surgery; patients aged \<75 years; patients unable to sign informed consent.

Locations (1)

ASST Spedali Civili

Brescia, Lombardy, Italy

Outcomes

Primary Outcomes

MPI and major morbidity

The primary goal of the FRAGIS (Frailty Assessment by Geriatric Investigation in Surgery) study was to evaluate the association between the MPI score and the occurrence of major postoperative complications within 30 days of CRC surgery.

Time frame: 30 days

Secondary Outcomes

Prediction of complication

The secondary goal was to develop a model to predict the individual risk of postoperative complications, allowing the appropriate patient selection for surgery.

Time frame: 90 days

Data from ClinicalTrials.gov

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