A Safety Study of KHK4951 in Healthy Volunteers and Patients With Wet Age-Related Macular Degeneration

Inclusion Criteria: Healthy Volunteers * Voluntary written informed consent to participate in the study * Japanese or white men 20 to \< 50 years at the time of informed consent * BMI 18.5 to \< 30.0 at screening * Intraocular pressure (study eye) 10.0 mm Hg to 21.0 mm Hg * Monocular or binocular visual acuity (corrected visual acuity if correction is required) ≥ 1.0 at screening Inclusion Criteria: Patients * Voluntary written informed consent to participate in the study * Age ≥ 50 years at the time of informed consent * AMD-associated by active subfoveal CNV lesions in the study eye or juxtafoveal CNV lesions with CNV-associated findings in the fovea in the study eye * CST ≥ 300 μm in the study eye at screening, as measured by OCT * BCVA score ≥ 23 letters in the study eye at screening and enrollment, as measured by the ETDRS visual acuity chart * BCVA score ≥ 58 letters in the non-study eye at screening, as measured by the ETDRS visual acuity chart * In subjects with prior treatment of the study eye with anti-vascular endothelial growth factor (anti-VEGF) drugs such as Beovu, Eylea, Lucentis, Avastin, or Macugen, presence of response to the anti-VEGF drug(s) as judged by the investigator or subinvestigator based OCT, FA, visual acuity, or other assessment results Exclusion Criteria: Healthy Volunteers * Current illness requiring treatment * History of ophthalmologic laser surgery, ophthalmologic surgery, nasolacrimal duct surgery, orany eyelid surgery affecting flow in the nasolacrimal duct * History of or current circulatory disease (e.g., cerebrovascular or cardiovascular disease) * History of or current dry eye * Abnormal findings on OCT at screening or enrollment examination Exclusion Criteria: Patients * Clinical findings or a history of conditions other than wAMD affecting the retina and choroid (e.g., diabetic retinopathy, diabetic macular edema, myopic CNV, retinal vein occlusion, or premacular membrane) in either of the eyes * Any of the following diseases in the study eye: * Glaucoma * Ischemic optic neuropathy * Retinitis pigmentosa * Current or history of vitreous hemorrhage or macular hole in the study eye * Any abnormality in the anterior segment of the eye or vitreous body that may affect fundus observation by OCT, color fundus photography, or fluorescein angiography