The study will examine the lymphatic functional and morphological status in patients with moderate tricuspid valve regurgitation compared to healthy age and gender-matched controls. The study will use t2 weighted MRI, Near-infrared fluorescence imaging, and plethysmography to examine the above-mentioned question.
The study will examine the lymphatic functional and morphological status in patients with moderate tricuspid valve regurgitation compared to healthy age and gender-matched controls. Subjects will be examined at one occasion using t2-weighted MRIs to evaluated lymphatic anatomy and Near-infrared fluorescence imaging for evaluation of superficial peripheral lymphatic function. Finally, the capillary filtration rate will be estimated using plethysmography.
Study Type
OBSERVATIONAL
Enrollment
18
Department of Cardiothoracic Surgery
Aarhus N, Central Jutland, Denmark
Thoracic duct tortuosity (centimeters/centimeters)
Based on MRI, the thoracic duct will be rendered and measured with regards to tortuosity (full length/straight length)
Time frame: 20 minutes
Thoracic duct volume (cubic centimetres)
Based on MRI, the thoracic duct will be rendered and measured with regards to volume.
Time frame: 30 minutes
Excess fluid (yes/no)
Based on MRI, the existence of excess fluid in the pericardial, thoracic and abdominal cavity will be accessed.
Time frame: 40 minutes
Peripheral lymphatic velocity (centimeters/second)
Peripheral lymphatic fluid velocity (centimeters/second) will be calculated based upon NIRF sequences.
Time frame: 1 hour
Peripheral lymphatic frequency (contractions/minute)
Peripheral lymphatic contraction frequency (contractions/minute) will be calculated based upon NIRF sequences.
Time frame: 1 hour 30 minutes
Capillary filtration
Evaluation of capillary filtration rate estimated using plethysmography
Time frame: 2 hours
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