Growing evidence of Tranexamic Acid (TXA) being used to reduce blood loss and blood transfusions in various guidelines. However, the adverse effects of TXA especially seizure has always been a problem of concern, especially in neurosurgery. Therefore, this study aims to provide a scientific evidence for the safety of TXA in supratentorial meningiomas resection patients.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
QUADRUPLE
Enrollment
228
20mg/kg TXA was prepared in a 50ml syringe for intravenous pump
0.9% saline was prepared in a 50ml syringe for intravenous pump
Beijing Tiantan Hospital
Beijing, Beijing Municipality, China
Early postoperative seizures within 7 days
Postoperative seizures were defined as a transient occurrence of involuntary movements, abnormal sensory phenomena, or an altered mental status that could not otherwise be explained.
Time frame: Within 7 days after surgery
The incidence of non-epileptic complications
Including intracranial hematoma, deep vein thrombosis, pulmonary embolism, cerebral venous sinus thrombosis, stroke, myocardial infarction, acute kidney infarction, anaemia, and infection.
Time frame: Within 7 days after the intervention
Estimated intraoperative blood loss
Estimated intraoperative blood loss = collected blood volume in the suction canister (ml) - volume of flushing (ml) + volume from gauze tampon (ml).
Time frame: During surgery
The changes in haemoglobin concentrations
The changes in haemoglobin concentrations between baseline and end of surgery.
Time frame: During surgery
The intraoperative blood transfusion volume and rate
The intraoperative blood transfusion volume and rate.
Time frame: During surgery
The intraoperative cell saver volume and rate
The intraoperative cell saver volume and rate.
Time frame: During surgery
This platform is for informational purposes only and does not constitute medical advice. Always consult a qualified healthcare professional.