Digital Wavefront Sensing

Medical University of Vienna30 enrolled

Overview

A holographic optical coherence tomography (H-OCT) setup is used to detect the wavefront by means of phase reconstruction.

H-OCT will be tested in this study for its suitability for the qualitative investigation of aberrometry. We aim to achieve a digital equivalent for wavefront calculation of the widespread analog procedure commonly used with conventional wavefront-aberrometers. The results will be compared with those from a conventional analog wavefront calculation method. In the course of this pilot study, 20 eyes of phakic and 10 eyes of pseudophakic subjects with suspected higher order aberrations will be examined using H-OCT.

Study Type

INTERVENTIONAL

Allocation

Purpose

BASIC_SCIENCE

Masking

NONE

Enrollment

Conditions

Wavefront Aberration, Corneal Refractive Errors

Interventions

Holographic optical coherence tomographyDEVICE

Descriptive wavefront analysis with holographic optical coherence tomography

Eligibility

Sex: ALLMin age: 18 YearsMax age: 85 YearsHealthy volunteers:

Medical Language ↔ Plain English

Inclusion Criteria: 1. Informed consent 2. Men and women aged between 18 and 85 years 3. Normal ophthalmic findings except refractive errors or suspected higher order aberrations 4. Normal findings in the medical history unless the investigator considers an abnormality to be clinically irrelevant Exclusion Criteria: 1. Hyperopia \> +6 Dpt. and Myopia \< -6 Dpt. 2. Known ophthalmic diseases such as age related macular degeneration, diabetic retinopathy, glaucoma, retinal detachment or previous ocular trauma and surgeries except cataract extraction 3. Participation in a clinical trial in the previous 3 weeks 4. Presence of any abnormalities preventing reliable measurements as judged by the investigator 5. Pregnancy, planned pregnancy or lactating

Outcomes

Primary Outcomes

Qualitative description of lower order aberrations (LOA)

Zernike terms, RMS-error, Strehl ratio

Time frame: 14 +/- 3 days

Qualitative description of higher order aberrations (HOA)

Zernike terms, root mean square error , Strehl ratio

Time frame: 14 +/- 3 days

Central Contacts

Doreen Schmidl, MD, PhD

CONTACT

40400 klin-pharmakologie@meduniwien.ac.at

Data from ClinicalTrials.gov

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