Dexmedetomidine Versus Ketamine Versus Midazolam in Endoscopic Procedures

National Cancer Institute, Egypt75 enrolled

Overview

This study aims to assess the safety and efficacy of dexmedetomidine versus ketamine versus midazolam combined with propofol in cancer patients undergoing gastrointestinal endoscopic procedures.

Comparison between using intravenous (IV) propofol combined with either IV dexmedetomidine or IV ketamine or IV midazolam; to study the effect of their combination on level of sedation and hemodynamic stability on adult patients scheduled for gastrointestinal endoscopic procedures.

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

TREATMENT

Masking

DOUBLE

Enrollment

Conditions

Sedation and Analgesia

Interventions

DexmedetomidineDRUG

intravenous dexmedetomidine 1 mic/kg

KetamineDRUG

ketamine 1mg/kg

MidazolamDRUG

midazolam 0.05 mg/kg

Eligibility

Sex: ALLMin age: 18 YearsMax age: 70 Years

Medical Language ↔ Plain English

Inclusion Criteria: * patients scheduled for gastrointestinal endoscopic procedures * ≥ Age 18 years * ASA I-II Exclusion Criteria: * Allergy to any of the used drugs * impaired renal or liver functions * hypertensive patients * patients with cardiovascular * cerebrovascular disease

Locations (1)

Walaa Y Elsabeeny

Cairo, Egypt

Outcomes

Primary Outcomes

Ramsy sedation score (RSS)

time to achievement of Ramsy sedation score (RSS) 3-4, Ramsy sedation scale score from 1 to 6, 1 meaning anxious and 6 meaning no response to stimulus

Time frame: 3 to 6 months

Data from ClinicalTrials.gov

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