Since the 1970s, ketamine has been used in clinical anesthesia treatment. Compared with ketamine, esketamine has a higher clearance rate, so it has a shorter recovery time after anesthesia. This feature also makes ketamine more suitable for pediatric dental patients.The purpose of this study was to investigate and compare the efficacy of esketamine sedation and fentanyl sedation in pediatric dental patients
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
PREVENTION
Masking
QUADRUPLE
Enrollment
48
The fentanyl group was prepared by 1ug/kg fentanyl in 5ml normal saline, assembled with 5ml injection, labeled as "Anesthesia inducer".
The esketamine group was prepared by 0.5mg/kg esketamine in 5ml normal saline, assembled with 5ml injection, labeled as "Anesthesia inducer".
Midazolam 0.05mg/kg+ "Anesthesia inducer" was applied to all patients for procedural induction by intravenous injection. According to the MOAA/S score of the patients, midazolam could be added 0.5mg per time at more than 2 minutes until the MOAA/S score reached 3, the maximum infusion dose of midazolam was less than 10mg and less than 0.1mg/kg.
Peking University Hospital of Stomatology
Beijing, Beijing Municipality, China
Hypoxemia
The incidence of intraoperative hypoxemia (Spo2\<92%)
Time frame: Day 0
Midazolam use
The total use of midazolam
Time frame: Day 0
Successful sedation
Success rate of sedation
Time frame: Day 0
Respiratory depression
Incidence of intraoperative respiratory depression and the need for airway support such as mandibular dragging
Time frame: Day 0
Agitation and delirium
The incidence of agitation and delirium during and after operation
Time frame: Day 0
Circulatory fluctuation
Occurrence of hypertension, hypotension, bradycardia, tachycardia and other side effects
Time frame: Day 0
Propofol requiring
Incidence of sedation requiring propofol
Time frame: Day 0
Time of successful sedation
The time when the MOAA/S score was equal to 3 points for the first time after patients were given anesthetic inducer
Time frame: Day 0
MOAA/S score in recovery room
MOAA/S score of patients every 15 minutes after entering the recovery room
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Time frame: Day 0
The time for Modified Observer Assessment of Sedation Score(MOAA/S)>4
The time for MOAA/S score to be greater than 4 since the end of clinical operation and the cessation of anesthetic infusion. MOAA/S is from 0 to 5, the higher of the score means the less sedative condition.
Time frame: Day 0
Directional force recovery time
Recovery time of directional force
Time frame: Day 0
Recall of intraoperative events
The child's recall of intraoperative events
Time frame: Day 0
Treatment comfort score
Patients' satisfaction score of treatment comfort. This score is from 0 to 10, the higher of the score means the more comfortable of the treatment patients received.
Time frame: Day 0
The incidence of complications
The incidence of patients suffered from pain, drowsiness, vomiting, nausea, mental emotion,within 1 day after treatment
Time frame: Day 1
Visual Analogue Scale(VAS) of pain in recovery room
Evaluate patients' VAS of pain every 15 minutes after entering the recovery room. This scale is from 0 to 10, the higher of the scale means the more painful patients feel.
Time frame: Day 0