The Combination of Endometrial Injury and Freeze All Strategy in Women With a History of RIF

National and Kapodistrian University of Athens60 enrolled

Overview

The investigators checked the hypothesis whether endometrial injury performed during the cycle before a frozen embryo transfer in women with RIF can improve pregnancy rates

After a freeze all cycle, participants were divided in two groups: an intervention group (n=30), who underwent endometrial injury before the transfer, and a control group (n=30), who underwent no other intervention. The primary outcome was clinical pregnancy rate, while secondary clinical and laboratory parameters. Baseline and cycle characteristics were also compared between groups.

Study Type

INTERVENTIONAL

Allocation

Purpose

TREATMENT

Masking

NONE

Enrollment

Conditions

Endometrial Injury Hysteroscopy Repeated Implantation Failures

Interventions

Endometrial injuryPROCEDURE

Endometrial injury was performed hysteroscopically after freeze all cycles and during the cycle before the frozen embryo transfer

Eligibility

Sex: FEMALEMin age: 25 YearsMax age: 42 YearsHealthy volunteers:

Medical Language ↔ Plain English

Inclusion Criteria: * Women with RIF under 42 years old * BMI 20-30 * Normal endometrial cavity * FSH \<15 IU/L * Absence of immunological or hematological disorder Exclusion Criteria: * women over 42 years old * FSH\>15 IU/L * women with chronic immunological or hematological disorder * stage III or IV of endometriosis * women with pathology concerning the endometrial cavity * women with a medical history of adnexectomy or oophorectomy

Locations (1)

National and Kapodistrian University of Athens

Athens, Greece

Outcomes

Primary Outcomes

Physiological parameter - Live birth rate

The complete expulsion or extraction from a woman of a product of fertilization, after 22 completed weeks of gestational age

Time frame: 22 weeks

Secondary Outcomes

Physiological parameter -Clinical pregnancy rate

A pregnancy diagnosed by ultrasonographic visualization of one or more gestational sacs or definitive clinical signs of pregnancy

Time frame: 7 weeks

Adverse event - Miscarriage

Spontaneous loss of a clinical pregnancy before 22 completed weeks of gestational age

Time frame: 22 weeks

Data from ClinicalTrials.gov

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