The Effects of Terminalia Chebula Fruit Extract on the Gut Microbiome and Skin Biophysical Properties

Inclusion Criteria: 1. Females aged 25 to 55 years of age 2. Subject must be able to read and comprehend study procedures and consent forms. 3. BMI 25-35 Exclusion Criteria: 1. Subjects must have no history of malignancy, kidney disease, or chronic steroid use. 2. No history of smoking or chewing tobacco or vaping nicotine based products within the past year or if the pack-year history of smoking tobacco is greater than 5 pack-years. 3. No history of anorexia 4. Those that are currently taking serotonin or SSRIs. 5. No intake of pomegranate containing drinks, walnuts, and strawberries two weeks prior to enrollment and throughout the study 6. Those who are unable to discontinue topical medications for two weeks. 7. Individuals who have had any medical or cosmetic procedure, such as laser resurfacing, or plastic surgery to the test site (face) within the last 6 months. This includes botulinum toxin, dermal fillers, collagen or other similar cosmetic procedure 8. Individuals who are currently using or during the past 30 days have used hydroquinone, or a retinoid such as Retin A, or other Rx/OTC Retinoid, or steroids. 9. Those who are unable to discontinue systemic antibiotics or oral probiotics for one month prior starting the study. 10. Those who are unable to discontinue their Triphala or Terminalia chebula regimen for one month prior to starting study. 11. Subjects who are postmenopausal or perimenopausal as determined by the investigator based on history or documented menopause 12. Males will be excluded to reduce the contribution from gender-based differences in testosterone which can affect sebum production on the face. 13. Those who are pregnant or breastfeeding 14. Those that are prisoners or cognitively impaired 15. Those who have a known allergy to Triphala or Terminalia chebula