The hypothesis is that from a cluster defined by a confirmed positive case of COVID-19 and its contact cases, it is possible to study the different expressions and clinical evolutions of COVID-19 infection and to explore the biological profiles related to the observed clinical history. Certain biological determinants (virological, immunological, microbological or gentic) could indeed be correlated with the clinical presentation and/or be useful for personalized care. The main objective is to study the relationship between the biological profiles observed and the clinical evolutions within the same cluster of transmission of the coronavirus SARS-CoV-2 (positive COVID-19 cases and contact subjects).
Subjects with a COVID-19 infection and thei contact cases (identification according to health insurance criteria, see "Améli.fr") will be offered a clinical evaluation and the takin of biological samples, whether they are hospitalized or via the outpatient screening channel. For the main objective: during the D0 visit, the subjects who agreed to participate in the study will have a clinical evaluation according to a standardized questionnaire and a nasopharyngeal swab, saliva, blood, stool and urine. For secondary objectives : longitudinal follow-up will be carried out for 21 days, for index cases and contact cases, whether they have a positive or negative RT-PCR test on D0. A final consultation will be carried out at M3. Nasopharyngeal samples, saliva, blood, stool and urine will be taken on D10 and D21. A blood test will be taken at M3 to carry out a COVID-19 serology.
Study Type
INTERVENTIONAL
Allocation
NA
Purpose
DIAGNOSTIC
Masking
NONE
Enrollment
100
Subjects with a COVID-19 infection and their contact cases (identification according to health insurance criteria, see "Améli.fr") will be offered a clinical evaluation and the takin of biological samples, whether they are hospitalized or via the outpatient screening channel. For the main objective: during the Day0 visit, the subjects who agreed to participate in the study will have a clinical evaluation according to a standardized questionnaire and a nasopharyngeal swab, saliva, blood, stool and urine. For secondary objectives : longitudinal follow-up will be carried out for 21 days, for index cases and contact cases, whether they have a positive or negative RT-PCR test on D0. A final consultation will be carried out at M3. Nasopharyngeal samples, saliva, blood, stool and urine will be taken on D10 and D21. A blood test will be taken at M3 to carry out a COVID-19 serology.
CHU de Clermont-Ferrand
Clermont-Ferrand, France
Virological profile
Nasopharyngeal SARS-CoV-2 viral load at day 0 by RT-PCR (in log or ΔCT)
Time frame: Day 0
Virological profile
Nasopharyngeal SARS-CoV-2 viral load at day 0 by RT-PCR (in log or ΔCT)
Time frame: Day 10
Virological profile
Nasopharyngeal SARS-CoV-2 viral load at day 0 by RT-PCR (in log or ΔCT)
Time frame: Day 21
Virological profile (serology)
SARS-CoV-2 serology by enzyme-linked immunosorbent assays or magnetic chemiluminescence enzyme immunoassay (IgG and IgM titers)
Time frame: Day 0
Virological profile (serology)
SARS-CoV-2 serology by enzyme-linked immunosorbent assays or magnetic chemiluminescence enzyme immunoassay (IgG and IgM titers)
Time frame: Day 10
Virological profile (serology)
SARS-CoV-2 serology by enzyme-linked immunosorbent assays or magnetic chemiluminescence enzyme immunoassay (IgG and IgM titers)
Time frame: Day 21
Immunological profile with blood level for markers of inflammation (cytokine)
cytokine panel by flow cytometry or enzyme-linked immunosorbent assay in pg/mL
Time frame: Day 0
Immunological profile with blood level for markers of inflammation (cytokine)
cytokine panel by flow cytometry or enzyme-linked immunosorbent assay in pg/mL
Time frame: Day 10
Immunological profile with blood level for markers of inflammation (cytokine)
cytokine panel by flow cytometry or enzyme-linked immunosorbent assay in pg/mL
Time frame: Day 21
Immunological profile with blood level for markers of inflammation
markers on immune cell subpopulation by RT-PCR or flow cytometry in CT value or %
Time frame: Day 0
Immunological profile with blood level for markers of inflammation
markers on immune cell subpopulation by RT-PCR or flow cytometry in CT value or %
Time frame: Day 10
Immunological profile with blood level for markers of inflammation
markers on immune cell subpopulation by RT-PCR or flow cytometry in CT value or %
Time frame: Day 21
Biochemical profile by blood dosage of CRP
CRP in mg/l
Time frame: Day 0
Biochemical profile by blood dosage of CRP
CRP in mg/l
Time frame: Day 10
Biochemical profile by blood dosage of CRP
CRP in mg/l
Time frame: Day 21
Biochemical profile by blood dosage of CRP
CRP in mg/l
Time frame: Day 90
Biochemical profile by blood dosage of ASAT/ALAT
ASAT/ALAT in U/L
Time frame: Day 0
Biochemical profile by blood dosage of ASAT/ALAT
ASAT/ALAT in U/L
Time frame: Day 10
Biochemical profile by blood dosage of ASAT/ALAT
ASAT/ALAT in U/L
Time frame: Day 21
Biochemical profile by blood dosage of ASAT/ALAT
ASAT/ALAT in U/L
Time frame: Day 90
Biochemical profile by blood dosage of LDH
LDH in U/L
Time frame: Day 0
Biochemical profile by blood dosage of LDH
LDH in U/L
Time frame: Day 10
Biochemical profile by blood dosage of LDH
LDH in U/L
Time frame: Day 21
Biochemical profile by blood dosage of LDH
LDH in U/L
Time frame: Day 90
Biochemical profile by blood dosage of Lactate
Lactate in mg/l
Time frame: Day 0
Biochemical profile by blood dosage of Lactate
Lactate in mg/l
Time frame: Day 10
Biochemical profile by blood dosage of Lactate
Lactate in mg/l
Time frame: Day 21
Biochemical profile by blood dosage of Lactate
Lactate in mg/l
Time frame: Day 90
Biochemical profile by blood dosage of D-Dimer
D-Dimer in µg/L
Time frame: Day 0
Biochemical profile by blood dosage of D-Dimer
D-Dimer in µg/L
Time frame: Day 10
Biochemical profile by blood dosage of D-Dimer
D-Dimer in µg/L
Time frame: Day 21
Biochemical profile by blood dosage of D-Dimer
D-Dimer in µg/L
Time frame: Day 90
Biochemical profile by blood dosage of Troponin
Troponin in µg/L
Time frame: Day 0
Biochemical profile by blood dosage of Troponin
Troponin in µg/L
Time frame: Day 10
Biochemical profile by blood dosage of Troponin
Troponin in µg/L
Time frame: Day 21
Biochemical profile by blood dosage of Troponin
Troponin in µg/L
Time frame: Day 90
Biochemical profile by blood dosage of Ferritin
Ferritin in µg/L
Time frame: Day 0
Biochemical profile by blood dosage of Ferritin
Ferritin in µg/L
Time frame: Day 10
Biochemical profile by blood dosage of Ferritin
Ferritin in µg/L
Time frame: Day 21
Biochemical profile by blood dosage of RAGE
RAGE (receptor of advanced end glycation products) by enzyme-linked immunosorbent assays in pg/mg total protein
Time frame: Day 0
Biochemical profile by blood dosage of RAGE
RAGE (receptor of advanced end glycation products) by enzyme-linked immunosorbent assays in pg/mg total protein
Time frame: Day 10
Biochemical profile by blood dosage of RAGE
RAGE (receptor of advanced end glycation products) by enzyme-linked immunosorbent assays in pg/mg total protein
Time frame: Day 21
Biochemical profile by blood dosage of SUPAR
SUPAR (soluble urokinase plasminogen activator receptor) by enzyme-linked immunosorbent assays in pg/mg total protein
Time frame: Day 0
Biochemical profile by blood dosage of SUPAR
SUPAR (soluble urokinase plasminogen activator receptor) by enzyme-linked immunosorbent assays in pg/mg total protein
Time frame: Day 10
Biochemical profile by blood dosage of SUPAR
SUPAR (soluble urokinase plasminogen activator receptor) by enzyme-linked immunosorbent assays in pg/mg total protein
Time frame: Day 21
Haematological profile by blood dosage of leukocytes
leukocytes in Giga/L
Time frame: Day 0
Haematological profile by blood dosage of leukocytes
leukocytes in Giga/L
Time frame: Day 10
Haematological profile by blood dosage of leukocytes
leukocytes in Giga/L
Time frame: Day 21
Haematological profile by blood dosage of leukocytes
leukocytes in Giga/L
Time frame: Day 90
Haematological profile by blood dosage of Red blood cells
Red blood cells in Tera/L
Time frame: Day 0
Haematological profile by blood dosage of Red blood cells
Red blood cells in Tera/L
Time frame: Day 10
Haematological profile by blood dosage of Red blood cells
Red blood cells in Tera/L
Time frame: Day 21
Haematological profile by blood dosage of Red blood cells
Red blood cells in Tera/L
Time frame: Day 90
Haematological profile by blood dosage of Hemoglobin
Hemoglobin in g/dL
Time frame: Day 0
Haematological profile by blood dosage of Hemoglobin
Hemoglobin in g/dL
Time frame: Day 10
Haematological profile by blood dosage of Hemoglobin
Hemoglobin in g/dL
Time frame: Day 21
Haematological profile by blood dosage of Hemoglobin
Hemoglobin in g/dL
Time frame: Day 90
Haematological profile by blood dosage of Hematocrit
Hematocrit in %
Time frame: Day 0
Haematological profile by blood dosage of Hematocrit
Hematocrit in %
Time frame: Day 10
Haematological profile by blood dosage of Hematocrit
Hematocrit in %
Time frame: Day 21
Haematological profile by blood dosage of Hematocrit
Hematocrit in %
Time frame: Day 90
Haematological profile by blood dosage of Mean corpuscular volume
Mean corpuscular volume in fL
Time frame: Day 0
Haematological profile by blood dosage of Mean corpuscular volume
Mean corpuscular volume in fL
Time frame: Day 10
Haematological profile by blood dosage of Mean corpuscular volume
Mean corpuscular volume in fL
Time frame: Day 21
Haematological profile by blood dosage of Mean corpuscular volume
Mean corpuscular volume in fL
Time frame: Day 90
Haematological profile by blood dosage of Mean corpuscular hemoglobin
Mean corpuscular hemoglobin in pg
Time frame: Day 0
Haematological profile by blood dosage of Mean corpuscular hemoglobin
Mean corpuscular hemoglobin in pg
Time frame: Day 10
Haematological profile by blood dosage of Mean corpuscular hemoglobin
Mean corpuscular hemoglobin in pg
Time frame: Day 21
Haematological profile by blood dosage of Mean corpuscular hemoglobin
Mean corpuscular hemoglobin in pg
Time frame: Day 90
Haematological profile by blood dosage of average corpuscular concentration of haemoglobin
Average corpuscular concentration of haemoglobin in g/dL
Time frame: Day 0
Haematological profile by blood dosage of average corpuscular concentration of haemoglobin
Average corpuscular concentration of haemoglobin in g/dL
Time frame: Day 10
Haematological profile by blood dosage of average corpuscular concentration of haemoglobin
Average corpuscular concentration of haemoglobin in g/dL
Time frame: Day 21
Haematological profile by blood dosage of average corpuscular concentration of haemoglobin
Average corpuscular concentration of haemoglobin in g/dL
Time frame: Day 90
Haematological profile by blood dosage of polynuclear neutrophil
polynuclear neutrophil in Giga/L
Time frame: Day 0
Haematological profile by blood dosage of polynuclear neutrophil
polynuclear neutrophil in Giga/L
Time frame: Day 10
Haematological profile by blood dosage of polynuclear neutrophil
polynuclear neutrophil in Giga/L
Time frame: Day 21
Haematological profile by blood dosage of polynuclear neutrophil
polynuclear neutrophil in Giga/L
Time frame: Day 90
Haematological profile by blood dosage of polynuclear eosinophils
polynuclear eosinophils in Giga/L
Time frame: Day 0
Haematological profile by blood dosage of polynuclear eosinophils
polynuclear eosinophils in Giga/L
Time frame: Day 10
Haematological profile by blood dosage of polynuclear eosinophils
polynuclear eosinophils in Giga/L
Time frame: Day 21
Haematological profile by blood dosage of polynuclear eosinophils
polynuclear eosinophils in Giga/L
Time frame: Day 90
Haematological profile by blood dosage of polynuclear basophils
polynuclear basophils in Giga/L
Time frame: Day 0
Haematological profile by blood dosage of polynuclear basophils
polynuclear basophils in Giga/L
Time frame: Day 10
Haematological profile by blood dosage of polynuclear basophils
polynuclear basophils in Giga/L
Time frame: Day 21
Haematological profile by blood dosage of polynuclear basophils
polynuclear basophils in Giga/L
Time frame: Day 90
Haematological profile by blood dosage of lymphocytes
lymphocytes in Giga/L
Time frame: Day 0
Haematological profile by blood dosage of lymphocytes
lymphocytes in Giga/L
Time frame: Day 10
Haematological profile by blood dosage of lymphocytes
lymphocytes in Giga/L
Time frame: Day 21
Haematological profile by blood dosage of lymphocytes
lymphocytes in Giga/L
Time frame: Day 90
Haematological profile by blood dosage of monocytes
monocytes in Giga/L
Time frame: Day 90
Haematological profile by blood dosage of monocytes
monocytes in Giga/L
Time frame: Day 0
Haematological profile by blood dosage of monocytes
monocytes in Giga/L
Time frame: Day 10
Haematological profile by blood dosage of monocytes
monocytes in Giga/L
Time frame: Day 21
Haematological profile by blood dosage of platelets
platelets in Giga/L
Time frame: Day 0
Haematological profile by blood dosage of platelets
platelets in Giga/L
Time frame: Day 10
Haematological profile by blood dosage of platelets
platelets in Giga/L
Time frame: Day 21
Haematological profile by blood dosage of platelets
platelets in Giga/L
Time frame: Day 90
Haematological profile by blood dosage of activated partial thromboplastin time
activated partial thromboplastin time in second/witness
Time frame: Day 0
Haematological profile by blood dosage of activated partial thromboplastin time
activated partial thromboplastin time in second/witness
Time frame: Day 10
Haematological profile by blood dosage of activated partial thromboplastin time
activated partial thromboplastin time in second/witness
Time frame: Day 21
Haematological profile by blood dosage of activated partial thromboplastin time
activated partial thromboplastin time in second/witness
Time frame: Day 90
Haematological profile by blood dosage of fibrinogen
fibrinogen in g/L
Time frame: Day 0
Haematological profile by blood dosage of fibrinogen
fibrinogen in g/L
Time frame: Day 10
Haematological profile by blood dosage of fibrinogen
fibrinogen in g/L
Time frame: Day 21
Haematological profile by blood dosage of fibrinogen
fibrinogen in g/L
Time frame: Day 90
Haematological profile by blood dosage of factor V
factor V in %
Time frame: Day 0
Haematological profile by blood dosage of factor V
factor V in %
Time frame: Day 10
Haematological profile by blood dosage of factor V
factor V in %
Time frame: Day 21
Haematological profile by blood dosage of factor V
factor V in %
Time frame: Day 90
SARS-CoV-2 salivary viral load
RT-PCR SARS-CoV-2 on saliva in ΔCT value or log10 copies per mL
Time frame: Day 0
SARS-CoV-2 salivary viral load
RT-PCR SARS-CoV-2 on saliva in ΔCT value or log10 copies per mL
Time frame: Day 10
SARS-CoV-2 salivary viral load
RT-PCR SARS-CoV-2 on saliva in ΔCT value or log10 copies per mL
Time frame: Day 21
Comparison of viral sequences
bioinformatic and statistical analyzes of viral sequences (arbitrary unit and p-values)
Time frame: Day 0
Comparison of viral sequences
bioinformatic and statistical analyzes of viral sequences (arbitrary unit and p-values)
Time frame: Day 10
Comparison of viral sequences
bioinformatic and statistical analyzes of viral sequences (arbitrary unit and p-values)
Time frame: Day 21
microbiota analysis
bioinformatic and statistical analyzes of microbiota (arbitrary unit and p-values)
Time frame: Day 0
microbiota analysis
bioinformatic and statistical analyzes of microbiota (arbitrary unit and p-values)
Time frame: Day 10
microbiota analysis
bioinformatic and statistical analyzes of microbiota (arbitrary unit and p-values)
Time frame: Day 21
environmental and societal factors (EPICE)
This platform is for informational purposes only and does not constitute medical advice. Always consult a qualified healthcare professional.
EPICE score (Assessment of precariousness and health inequalities in examination centers Health) at day 0 from 0 to 100
Time frame: Day 0
environmental and societal factors
eating habits
Time frame: Day 0
environmental and societal factors
eating habits
Time frame: day 10
environmental and societal factors
eating habits
Time frame: day 21
environmental and societal factors
eating habits
Time frame: day 90
environmental and societal factors (SF-36)
SF-36 score (quality of life by Gardenal O) from 0 to 100
Time frame: Day 0
environmental and societal factors (SF-36)
SF-36 score (quality of life by Gardenal O) from 0 to 100
Time frame: day 10
environmental and societal factors (SF-36)
SF-36 score (quality of life by Gardenal O) from 0 to 100
Time frame: day 21
environmental and societal factors (SF-36)
SF-36 score (quality of life by Gardenal O) from 0 to 100
Time frame: day 90
environmental and societal factors (Physical activity)
Physical activity score (by J. Ricci et L. Gagnon test for adults and ActiFitY test for children) from 0 to 100
Time frame: Day 0
environmental and societal factors (Physical activity)
Physical activity score (by J. Ricci et L. Gagnon test for adults and ActiFitY test for children) from 0 to 100
Time frame: day 10
environmental and societal factors (Physical activity)
Physical activity score (by J. Ricci et L. Gagnon test for adults and ActiFitY test for children) from 0 to 100
Time frame: day 21
environmental and societal factors (Physical activity)
Physical activity score (by J. Ricci et L. Gagnon test for adults and ActiFitY test for children) from 0 to 100
Time frame: day 90
body weight
body weight in kg
Time frame: Day 0
body weight
body weight in kg
Time frame: day 10
body weight
body weight in kg
Time frame: day 21
body weight
body weight in kg
Time frame: day 90
oxygen saturation
oxygen saturation in %
Time frame: Day 0
oxygen saturation
oxygen saturation in %
Time frame: day 10
oxygen saturation
oxygen saturation in %
Time frame: day 21
oxygen saturation
oxygen saturation in %
Time frame: day 90
Respiratory rate
Respiratory rate per minute
Time frame: Day 0
Respiratory rate
Respiratory rate per minute
Time frame: day 10
Respiratory rate
Respiratory rate per minute
Time frame: day 21
Respiratory rate
Respiratory rate per minute
Time frame: day 90
cardiac frequency
cardiac frequency per minute
Time frame: Day 0
cardiac frequency
cardiac frequency per minute
Time frame: day 10
cardiac frequency
cardiac frequency per minute
Time frame: day 21
cardiac frequency
cardiac frequency per minute
Time frame: day 90
lung damage
Lung damage on auscultation in terms of presence/absence
Time frame: Day 0
lung damage
Lung damage on auscultation in terms of presence/absence
Time frame: day 10
lung damage
Lung damage on auscultation in terms of presence/absence
Time frame: day 21
lung damage
Lung damage on auscultation in terms of presence/absence
Time frame: day 90
lung evolution
CT san in terms of normal/abnormal (children and pregnant women not concerned)
Time frame: day 90
blood pressure
Dysatolic/systolic blood pressure in mmHg
Time frame: Day 0
blood pressure
Dysatolic/systolic blood pressure in mmHg
Time frame: day 10
blood pressure
Dysatolic/systolic blood pressure in mmHg
Time frame: day 21
blood pressure
Dysatolic/systolic blood pressure in mmHg
Time frame: day 90
body temperature
Body temperature in °C
Time frame: Day 0
body temperature
Body temperature in °C
Time frame: day 10
body temperature
Body temperature in °C
Time frame: day 21
body temperature
Body temperature in °C
Time frame: day 90
clinical exam (skin)
Skin mottling in terms of presence/absence
Time frame: Day 0
clinical exam (skin)
Skin mottling in terms of presence/absence
Time frame: day 10
clinical exam (skin)
Skin mottling in terms of presence/absence
Time frame: day 21
clinical exam (skin)
Skin mottling in terms of presence/absence
Time frame: day 90
clinical exam (polypnea)
polypnea in terms of presence/absence
Time frame: Day 0
clinical exam (polypnea)
polypnea in terms of presence/absence
Time frame: day 10
clinical exam (polypnea)
polypnea in terms of presence/absence
Time frame: day 21
clinical exam (polypnea)
polypnea in terms of presence/absence
Time frame: day 90
denutrition
denutrition in terms of presence/absence
Time frame: Day 0
denutrition
denutrition in terms of presence/absence
Time frame: day 10
denutrition
denutrition in terms of presence/absence
Time frame: day 21
denutrition
denutrition in terms of presence/absence
Time frame: day 90
Antibiotic treatment
Antibiotic treatment in terms of presence/absence with precision if necessary
Time frame: Day 0
Antibiotic treatment
Antibiotic treatment in terms of presence/absence with precision if necessary
Time frame: day 10
Antibiotic treatment
Antibiotic treatment in terms of presence/absence with precision if necessary
Time frame: day 21
Antibiotic treatment
Antibiotic treatment in terms of presence/absence with precision if necessary
Time frame: day 90
Steroidal anti-inflammatory treatment
Steroidal anti-inflammatory treatment in terms of presence/absence with precision if necessary
Time frame: Day 0
Steroidal anti-inflammatory treatment
Steroidal anti-inflammatory treatment in terms of presence/absence with precision if necessary
Time frame: day 10
Steroidal anti-inflammatory treatment
Steroidal anti-inflammatory treatment in terms of presence/absence with precision if necessary
Time frame: day 21
Steroidal anti-inflammatory treatment
Steroidal anti-inflammatory treatment in terms of presence/absence with precision if necessary
Time frame: day 90
Anti-diabetic treatment
Anti-diabetic treatment in terms of presence/absence with precision if necessary
Time frame: Day 0
Anti-diabetic treatment
Anti-diabetic treatment in terms of presence/absence with precision if necessary
Time frame: day 10
Anti-diabetic treatment
Anti-diabetic treatment in terms of presence/absence with precision if necessary
Time frame: day 21
Anti-diabetic treatment
Anti-diabetic treatment in terms of presence/absence with precision if necessary
Time frame: day 90
Gastric protector treatment
Gastric protector treatment in terms of presence/absence with precision if necessary
Time frame: Day 0
Gastric protector treatment
Gastric protector treatment in terms of presence/absence with precision if necessary
Time frame: day 10
Gastric protector treatment
Gastric protector treatment in terms of presence/absence with precision if necessary
Time frame: day 21
Gastric protector treatment
Gastric protector treatment in terms of presence/absence with precision if necessary
Time frame: day 90
chills
chills in terms of presence/absence
Time frame: Day 0
chills
chills in terms of presence/absence
Time frame: day 10
chills
chills in terms of presence/absence
Time frame: day 21
chills
chills in terms of presence/absence
Time frame: day 90
Myalgia
Myalgia in terms of presence/absence
Time frame: Day 0
Myalgia
Myalgia in terms of presence/absence
Time frame: day 10
Myalgia
Myalgia in terms of presence/absence
Time frame: day 21
Myalgia
Myalgia in terms of presence/absence
Time frame: day 90
Anorexia
Anorexia in terms of presence/absence
Time frame: Day 0
Anorexia
Anorexia in terms of presence/absence
Time frame: day 10
Anorexia
Anorexia in terms of presence/absence
Time frame: day 21
Anorexia
Anorexia in terms of presence/absence
Time frame: day 90
Rhinitis
Rhinitis in terms of presence/absence
Time frame: Day 0
Rhinitis
Rhinitis in terms of presence/absence
Time frame: day 10
Rhinitis
Rhinitis in terms of presence/absence
Time frame: day 21
Rhinitis
Rhinitis in terms of presence/absence
Time frame: day 90
Confusion
Confusion in terms of presence/absence
Time frame: Day 0
Confusion
Confusion in terms of presence/absence
Time frame: day 10
Confusion
Confusion in terms of presence/absence
Time frame: day 21
Confusion
Confusion in terms of presence/absence
Time frame: day 90
Asthenia
Asthenia in terms of presence/absence
Time frame: Day 0
Asthenia
Asthenia in terms of presence/absence
Time frame: day 10
Asthenia
Asthenia in terms of presence/absence
Time frame: day 21
Asthenia
Asthenia in terms of presence/absence
Time frame: day 90
Falls at home
Falls at home in terms of presence/absence
Time frame: Day 0
Falls at home
Falls at home in terms of presence/absence
Time frame: day 10
Falls at home
Falls at home in terms of presence/absence
Time frame: day 21
Falls at home
Falls at home in terms of presence/absence
Time frame: day 90
Insomnia
Insomnia in terms of presence/absence
Time frame: Day 0
Insomnia
Insomnia in terms of presence/absence
Time frame: day 10
Insomnia
Insomnia in terms of presence/absence
Time frame: day 21
Insomnia
Insomnia in terms of presence/absence
Time frame: day 90
Angina
Angina in terms of presence/absence
Time frame: Day 0
Angina
Angina in terms of presence/absence
Time frame: day 10
Angina
Angina in terms of presence/absence
Time frame: day 21
Angina
Angina in terms of presence/absence
Time frame: day 90
Ageusia
Ageusia in terms of presence/absence
Time frame: Day 0
Ageusia
Ageusia in terms of presence/absence
Time frame: day 10
Ageusia
Ageusia in terms of presence/absence
Time frame: day 21
Ageusia
Ageusia in terms of presence/absence
Time frame: day 90
Respiratory complaints
Respiratory complaints in term of SRIpr score from 0 to 100
Time frame: Day 0
Respiratory complaints
Respiratory complaints in term of SRIpr score from 0 to 100
Time frame: day 2
Respiratory complaints
Respiratory complaints in term of SRIpr score from 0 to 100
Time frame: day 4
Respiratory complaints
Respiratory complaints in term of SRIpr score from 0 to 100
Time frame: day 6
Respiratory complaints
Respiratory complaints in term of SRIpr score from 0 to 100
Time frame: day 8
Respiratory complaints
Respiratory complaints in term of SRIpr score from 0 to 100
Time frame: day 10
Respiratory complaints
Respiratory complaints in term of SRIpr score from 0 to 100
Time frame: day 21
Respiratory complaints
Respiratory complaints in term of SRIpr score from 0 to 100
Time frame: day 90
transmission rate
Rate of viral transmission determine by bioinformatic and statistical analyzes in %
Time frame: Day 0
transmission rate
Rate of viral transmission determine by bioinformatic and statistical analyzes in %
Time frame: day 10
transmission rate
Rate of viral transmission determine by bioinformatic and statistical analyzes in %
Time frame: day 21
prolonged viral shedding
Prolonged viral shedding evaluate by RT-PCR (CT value or log10 copies per mL)
Time frame: between day 0 and day 21