This study is meant to assess the lung mechanics in SARS-CoV-2 induced acute respiratory failure. A precise characterisation of lung mechanics and heart-lung-interactions might allow a better understanding of SARS-CoV-2 induced acute respiratory failure and thus lead to better mechanical ventilation strategies. This monocentric, observational study of critically ill COVID-19 patients in the ICU, will employ impedance tomography, right-heart catheterization, oesophageal pressure measurements, indirect calorimetry as well as classic mechanical ventilation parameters to characterise the mechanical characteristics of the lung as well as the heart-lung interactions in SARS-CoV-2 induced acute respiratory failure.
Study Type
OBSERVATIONAL
Enrollment
25
Impedance tomography, right-heart catheterization, oesophageal pressure measurements, indirect calorimetry and classic mechanical ventilation parameters
Institute of Intensive Care Medicine, University Hospital Zurich
Zurich, Switzerland
RECRUITINGTime dependent compliance change
Compliance change over the length of mechanical ventilation
Time frame: Mixed Model Assessment of compliance over time until extubation (measurements every 2 days up to 90 days)
PEEP and time dependent change in dead space
Change in Dead Space over the length of mechanical ventilation
Time frame: Mixed Model Assessment of Dead Space over time until extubation (measurements every 2 days up to 90 days)
PEEP and time dependent change in shunt fraction
Change in shunt fraction over the length of mechanical ventilation
Time frame: Mixed Model Assessment of shunt fraction over time until extubation (measurements every 2 days up to 90 days)
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