This is a single-center observational study on adolescents to determine predictors of the early steps of the formation of atherosclerosis and to quantify their influence on Intima-Media-Thickness of the carotid artery and the aorta and on the Pulse-Wave Velocity. A long-term follow-up by means of record linkage is furthermore planned to evaluate the effect of early atherosclerosis and the cardiovascular risk profile on future morbidity with a special focus cardio- and cerebrovascular events.
EVA4YOU is a cross-sectional study enrolling 3000 students and apprentices aged between 14 and 19 years. Examinations are conducted at schools and companies throughout Tyrol, Austria and include laboratory measurements; standardized medical interviews; anthropometry; liver elastography; ultrasonography of the carotid artery and the aorta, and blood pressure, bioelectrical impedance; visceral abdominal fat-tissue-thickness measurement, pulse-wave velocity measurements. The study hypothesis is that the cardiovascular risk factors measured already influence the formation of atherosclerosis (measured as carotid and aortic Intima-Media Thickness and Pulse-Wave-Velocity) in adolescents. A long-term follow-up by means of record linkage is furthermore planned to evaluate the effect of early atherosclerosis and the cardiovascular risk profile on future morbidity with a special focus cardio- and cerebrovascular events.
Study Type
OBSERVATIONAL
Enrollment
1,517
Medical University Innsbruck
Innsbruck, Tyrol, Austria
Determinants of Intima-Media Thickness (carotid and aortic)
Predictors to be examined include: Blood Pressure, BMI/body composition, Smoking, Physical Activity, Family History, Lipid and Glucose Metabolism, NAFLD, Diet, Sex, Age used as predictors in multiple regression analysis
Time frame: Day 1
Determinants of the Pulse-Wave Velocity [m/s]
Predictors to be examined include: Blood Pressure, BMI/body composition, Smoking, Physical Activity, Family History, Lipid and Glucose Metabolism, NAFLD, Diet, Sex, Age used as predictors in multiple regression analysis The pulse-wave velocity \[m/s\] is measured by using the Vicorder, an oscillometric pulse-wave measurement device.
Time frame: Day 1
Predictors of later cardio- and cerebrovascular disease (events and mortality) by record linkage
Occurence of major adverse cardiovascular events (yes/no, time to event), assessed by means of automated detection of these events by record linkage
Time frame: every 2-5 years, on average for the duration of 50 years
Prevalence of traditional cardiovascular risk and lifestyle factors and descripition of high-risk populations
Time frame: Day 1
Time trends in risk profiles by comparison to data from the Early Vascular Ageing (EVA) study, NCT03929692
Time frame: 8 years
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