Use of a Non-Invasive Brainstem Neuromodulation Device to Improve Neurovascular Status in Parkinson's Disease

Inclusion Criteria: * Must be 21-85 years old * Diagnosed with Parkinson's Disease * Within driving distance of Atrium Health Wake Forest Baptist (Winston-Salem, NC) * Responsive to Parkinson's medication for a minimum of 3 years * Have ability to reliably use the investigational device * Understand and complete all assessments (provided in English only) * Be able to have 3 separate MRI scans (1.5 hours per MRI) * Have a study partner/regular caregiver that is willing to participate in the trial * Demonstrate moderate burden of motor symptoms and non-motor symptoms * Consent to being videotaped during motor examination visit * Willing to answer questions related to sexual interest, arousal and performance in an interview with study staff Exclusion Criteria: * Cannot attend all study visits (4 on-site visits) or complete all study activities * Heart attack, angina, or stroke within the past year * Use medications that regulate heart rate * Have a history or prior diagnosis of dementia * Receiving deep brain stimulation therapy * Treated with a pump for continuous delivery of dopamine replacement therapy * Use of Apomorphine rescue * Works night shifts * Have any significant co-morbidity such as stroke, brain tumor, epilepsy, Alzheimer's disease, multiple sclerosis, ALS, atypical Parkinsonism, or aneurysm * History or evidence of unstable mood disorder or demonstrates evidence of suicidality * Hearing aids that are implanted or cannot be easily removed and replaced, such as cochlear implants * Chronic ringing in the ears for more than 3 months * Diagnosed with traumatic brain injury with ongoing symptoms * Recent history of substance abuse and/or dependence (alcohol or other drugs) * Diagnosed balance dysfunction * Eye surgery within the previous 3 months * Ear surgery within the previous 6 months * Active ear infection, perforated tympanic membrane, or inner ear inflammation * Recent history of frequent ear infections (≥ 1 per year over the past two years) * Contraindications for MRI scans, such as metal implants or a pacemaker * Currently enrolled or have participated in another interventional clinical trial within the last 30 days * Taking medication for vomiting or nausea more than 2 times per week, consistently * Ongoing symptoms from a COVID-19 infection that includes one or more of the exclusion criteria listed above * Planned surgery scheduled to occur during the clinical trial that requires sedation and/or would typically be followed with a prescription for pain management * Women who are pregnant or plan to become pregnant during the the study Women of child-bearing potential (i.e., are not yet 3 years removed from their first menopausal symptom), who are not abstinent or exclusively in same sex relationships must: Test negative for pregnancy as indicated by a negative urine pregnancy test Agree to use an approved contraception method