the Association Between Thyroid Hormones and Metabolic Components in Patients With Obesity

Shanghai 10th People's Hospital373 enrolled

Overview

This study collected clinical data of obese patients with euthyroid function, including age, gender, height, weight, BMI, waist circumference, blood pressure, fasting blood sugar, blood sugar 2 hours after sugar load, fasting plasma high-density lipoprotein cholesterol, fasting three acyl glycerin, free iodine thyroid hormone (FT3) and free thyroid hormones (FT4), thyroid stimulating hormone (TSH), follow-up information and etc. Via analyzing the data, the investigators want to investigate the association between thyroid hormones (THs) and metabolic components in obese patients with euthyroid function and to present the cutoff values of THs in order to provide new information for the risk stratification of metabolic syndrome in obese patients with euthyroid function.

Study Type

OBSERVATIONAL

Enrollment

373

Conditions

Obesity Euthyroid Condition Metabolic Syndrome

Interventions

no intervention

Eligibility

Sex: ALLMin age: 18 YearsMax age: 65 YearsHealthy volunteers:

Medical Language ↔ Plain English

Inclusion Criteria: * 1\) age ranged from 18-65 years old, 2) BMI over 27.9kg/m2,3)TSH，FT4, and FT3 within the range of 0.38-4.34mIU/L, 10.5-24.4mIU/L, and 2.8-6.3mIU/L, respectively. Exclusion Criteria: * secondary cause of obesity such as hypothalamic obesity, Cushing syndrome, and hypophysis dysfunction, etc.,2)pregnancy or location, 3) severe heart, liver and kidney dysfunction

Outcomes

Primary Outcomes

meet the criteria of metabolism in the 2017 Chinese guideline

1. Abdominal obesity (or central obesity), male abdominal circumference ≥90cm, female abdominal circumference ≥85 cm; 2. Hypertension, those who have been diagnosed with hypertension and are in treatment and (or) blood pressure ≥130/85mmHg (1mmHg = 0.133kPa); 3. Hyperglycemia, those who have been diagnosed with diabetes and are treated and (or) fasting blood glucose ≥6.1mmol/L or 2h blood glucose ≥7.8mmol/L after glucose load; 4. Fasting high-density lipoprotein cholesterol (HDL-C) \<1.04mmol/L; 5. Fasting triacylglycerol ≥1.70mmol/L.

Time frame: 2015-2020

Secondary Outcomes

high uric acid

female patients with uric acid over 360 umol/L and male female patients with uric acid over 420 umol/L

Time frame: 2015-2020

FBG≥6.1mmol/L

patients with fasting blood glucose 6.1mmol/L or more.

Time frame: 2015-2020

BG120≥7.8mmol/L

patients with 2 hour blood glucose 7.8mmol/L or more.

Time frame: 2015-2020

FINS≥24.9 pmol/ml

patients with fasting insulin 24.9 pmol/ml or more.

Time frame: 2015-2020

FCP≥4.4nmol/L

patients with fasting C-peptide 4.4nmol/L or more.

Time frame: 2015-2020