Preventive Treatment Of Latent Tuberculosis Infection In People With Diabetes Mellitus

Inclusion Criteria: 1. Enrolled in diabetes care with a history of DM and current use of anti-diabetic medication ('known DM'); OR in the absence of anti-diabetic medication an HbA1c of =6.5% (48 mmol/mol) or a fasting venous plasma glucose of =7.0 mmol (126 mg/dl). For those with no previously known DM a repeat test above the diagnostic cut-point is required to confirm the diagnosis ('new DM') 2. Adult (18 years or older) 3. Diagnosed with LTBI, defined as a positive IGRA test or TST reactivity =10 mm 4. Voluntarily signed Informed Consent Form 5. If sexually active, willing to use an effective contraceptive method for the duration of preventive therapy. Exclusion Criteria: 1. Weight \<45 kg 2. Previous TB disease, defined as either bacteriologically confirmed or clinically diagnosed and treated 3. Treatment with a rifamycin medication or isoniazid in the previous 2 years. 4. Diagnosis of probable or definite TB during screening 5. Confirmed HIV-infection or receiving antiretroviral treatment 6. Liver dysfunction, defined as serum aspartate aminotransferase (AST) level 5 times the upper limit of normal 7. Pregnant or planning to become pregnant in the next 3 months, or lactating 8. Known allergy/sensitivity or any hypersensitivity to components of study drugs or their formulation 9. Other conditions inapplicable for participation in this study, such as likely to fail to adhere to study commitment or to complete the whole study, at the discretion of the site investigator