Tuberculosis (TB) is still the leading cause of death in HIV-infected patients. Early diagnosis of TB substantially improves the survival of HIV-infected patients. Urine based detection of lipoarabinomannan (LAM) provides promising methods for quick diagnosis of TB in HIV-infected patients. However, the sensitivity and specificity of TB-LAM is still not well established, especially in area where non-tuberculosis mycobacterium is also prevalence. Here we aimed to evaluate the clinical utility of TB-LAM in diagnosis of active TB in hospitalized HIV-infected patients.
Study Type
INTERVENTIONAL
Allocation
NA
Purpose
DIAGNOSTIC
Masking
NONE
Enrollment
400
Subjects also undergo clinical evaluation including CT, sputum smear, Gene Xpert and mycobacterial culture.
Sensitivity against microbiological reference standard
Number of TB-LAM positive/Number of positive by culture or Gene Xpert
Time frame: 2 months
Specificity against microbiological reference standard
1-Number of TB-LAM negative/Number of negative by culture or Gene Xpert or smear
Time frame: 2 months
Sensitivity against composite reference standard
Number of TB-LAM positive/Number of active TB diagnosed clinically
Time frame: 2 months
Specificity against composite reference standard
1-Number of TB-LAM negative/Number of TB excluded
Time frame: 2 months
This platform is for informational purposes only and does not constitute medical advice. Always consult a qualified healthcare professional.