Aims of this study are to observe the correlation between ABCB1、VDR、TBX21、NR3C1 and other gene polymorphisms and the effect of glucocorticoid shock therapy on neuromyelitis optica. Investigators plan to include patients with neuromyelitis optica who will receive glucocorticoid shock therapy prospectively. The patients are divided into glucocorticoid sensitive (GS) group and glucocorticoid resistance (GR) group according to the change of central vision after treatment. Patients' clinical data will be collected and blood samples are needed for single nucleotide polymorphism (SNP) typing test. Through statistical analysis, the data differences between GS group and GR group were compared, and the effects of clinical indexes and gene polymorphisms on the efficacy of glucocorticoid shock therapy in the treatment of neuromyelitis optica should be analyzed.
Study Type
OBSERVATIONAL
Enrollment
350
methylprednisolone pulse therapy: 500-1000mg/d，３-５ｄ
Beijing Tongren Hospital
Beijing, China
RECRUITINGthe change of best corrected visual acuity (BCVA)
Test BCVA before and after the treatment of methylprednisolone pulse therapy, and calculate the change value
Time frame: 3 day after the treatment of methylprednisolone pulse therapy
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