A Study of Anti-PD-L1 Antibody ZKAB001 Combined With Albumin-bound Paclitaxel in Advanced Urothelial Carcinoma

Inclusion Criteria: * Age ≥18 years old; * Pathologically confirmed urothelial carcinoma; * Terminal patients who have not received treatment or for the first time recurrence more than 6 months after the end of adjuvant chemotherapy after surgery; * Evaluable lesions based on RECIST V1.1; * ECOG score 0-1; * Estimated life expectancy \>3 months; * The function of important organs meets the following requirements; * The subjects voluntarily joined the study, signed informed consent, had good compliance, and cooperated with follow-up. Exclusion Criteria: * Previously received drugs targeting PD-1, PD-L1, PD-L2 or other treatments targeting T cell costimulation or checkpoint channels; * Received systemic corticosteroid immunosuppressants 2 weeks before the study; * Suffer from active meningeal metastasis or uncontrolled, untreated brain metastasis; * Severe cardiovascular disease, such as New York Heart Association (New York Heart Association,NYHA standard) Grade 3-4 heart failure, unstable angina pectoris, unstable arrhythmia, or color heart photo indicates LVEF (left ventricular ejection fraction) \< 50%; * Previous hypersensitivity to monoclonal antibodies; * The patient has known, active or suspected autoimmune diseases. The following conditions are allowed: skin diseases that do not require systemic treatment (such as vitiligo, psoriasis), type I diabetes, autoimmune hypothyroidism with hormone replacement therapy; * The study drug suffered from other active malignant tumors within 5 years before the first use of the drug. Cured localized tumors, such as basal cell carcinoma of the skin, squamous cell carcinoma of the skin, superficial bladder cancer, carcinoma in situ of the prostate, carcinoma in situ of the cervix, carcinoma in situ of the breast, etc., can be included in the group; * Active hepatitis B or C (unless HBV-DNA titer \< 500IU/mL or copy number \< 1000copies/ml, HCV-RNA negative after antiviral treatment can be included in), HIV positive or known history of acquired immunodeficiency syndrome; * Severe infection existed before screening, including but not limited to, infections requiring hospitalization, bacteremia, severe pneumonia, etc; * There has been active pulmonary tuberculosis in the past year, whether treated or not; * Live attenuated vaccine was used within 28 days prior to screening; * Patients who have previously received allogeneic bone marrow transplantation or solid organ transplantation; * Have received any other experimental drug treatment within 28 days prior to signing ICF; * Pregnant or lactating women; * Patients of childbearing age who refuse to use effective contraception; * Other researchers believe that it is not suitable to join the group.