Evaluation of EnVisio SmartClip for Intraoperative Localization of Breast Masses

Inclusion Criteria: * Participants must have at least one and up to 3 sonographically or mammographically identifiable in-breast or axillary targets and consent to undergo a surgical resection using the SmartClip localization system at the McKinley operative suites at Moffitt Cancer Center. Multiple sites for localization may be used, up to a maximum of 3 SmartClips per patient. Mammographically or sonographically visible biopsy clips may be used as a localizing target. * Participants must be age \> or = 18 years. Exclusion Criteria: * Participants with sonographically or mammographically occult target lesions * Participants with greater than 35cm chest to bust depth * Participants undergoing mastectomy for resection of the targeted lesion * Inability to undergo surgery at the McKinley OR suites due to institutional anesthesia guidelines * Patients requiring use of more than 3 SmartClips to localize targets