Calcium Electroporation in Patients With Cell Changes in the Esophagus

Inclusion Criteria: 1. Male or female ≥18 years old. 2. Histological verified Barrett's esophagus high-grade dysplasia (BE HGD) 3. Expected survival \> 3 months. 4. Performance status Eastern Cooperative Oncology Group (ECOG)/World Health Organization (WHO) ≤ 2. 5. Platelets ≥ 50 billion/l, International Normalized Ratio (INR) \< 1.5. Medical correction is allowed, e.g. correction of a high International Normalized Ratio (INR) using vitamin K. 6. Subjects must be willing and able to comply with the procedure, such as agreed follow-up visits. 7. Sexually active men and fertile women must use adequate contraception during this trial 8. Subjects must give written informed consent. Exclusion Criteria: 1. Coagulation disorder that cannot be corrected. 2. Subjects with a clinically significant cardiac arrhythmia. 3. Concurrent treatment with an investigational medicinal product 4. Patients with any other clinical condition or prior therapy that, in the opinion of the investigator, would make the patient unsuitable for the study or unable to comply with the study requirements. 5. Pregnancy or lactation A medical doctor will always be responsible for final inclusion of the subject.