Intrauterine Granulocyte colony stimulating factor (GCSF) was compared with intrauterine Human Chorionic Gonadotropin (HCG) in increasing clinical pregnancy rate as a primary outcome and ultrasound imaging of gestational sac as a secondary outcome.
Two hundred females with history of recurrent implantation failure and undergoing Intracytoplasmic Sprem injection (ICSI) were randomized into two groups; the first group (100 patients) received intrauterine Granulocyte colony stimulating factor (GCSF) and the second group (100) received intrauterine Human Chorionic Gonadotropin (HCG) at ovum pick up day. The clinical pregnancy rate was evaluated as a primary outcome after 14 days and ultrasound imaging of gestational sac was evaluated as a secondary outcome after 6 weeks.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
NONE
Enrollment
200
GCSF was intrauterine injected once at ovum pick up day
500 IU of HCG was injected intrauterine once at ovum pick up day
clinical pregnancy rate
Clinical pregnancy was evaluated by high HCG levels
Time frame: after 14 days from positive pregnancy test
Gestational sac imaging
ultrasound imaging of Gestational sac after 6 weeks of pregnancy
Time frame: 6 weeks of pregnancy
This platform is for informational purposes only and does not constitute medical advice. Always consult a qualified healthcare professional.