This research compare the effects of low carbohydrate intake and consumption of 3 eggs per day, and low energy diet on diabetes control and biomarkers of CVD in obese people.
This research study examines the effects of changes in weight, metabolism of glucose and cholesterol in the blood through diet and behavior modification. The main objective of this study was to compare the effects of low carbohydrate intake and consumption of 3 eggs per day, and low energy diet on diabetes control and biomarkers of CVD in obese people. In addition, HDL quantity and size as well as HDL function was compared between the group who ate the whole egg and the group who did not eat the yolk.
Study Type
INTERVENTIONAL
Allocation
NON_RANDOMIZED
Purpose
TREATMENT
Masking
NONE
Enrollment
76
Volunteers will be instructed on dietary recommendation throughout the research program to achieve a stable daily energy intake.
Faculty of Medicine Siriraj Hospital, Mahidol University
Bangkok Noi, Bangkok, Thailand
Changes in weight following dietary intervention
weight (kg) analysis
Time frame: Baseline and after 12 weeks
Changes in body mass index following dietary intervention
body mass index (kg/m\^2) analysis
Time frame: Baseline and after 12 weeks
Changes in waist circumference following dietary intervention
waist circumference (cm) analysis
Time frame: Baseline and after 12 weeks
Changes in lipid profiles concentration following dietary intervention
Triglycerides (mg/dl), Cholesterol (mg/dl), HDL-cholesterol (mg/dl) and LDL-cholesterol (mg/dl) concentration analysis
Time frame: Baseline and after 12 weeks
Changes in blood glucose and insulin concentration following dietary intervention
HbA1C (%), glucose (mg/dl) and insulin (mg/dl) concentration analysis
Time frame: Baseline and after 12 weeks
Changes in betahydroxybutirate concentration following dietary intervention
betahydroxybutirate (mmol/L) concentration analysis
Time frame: Baseline and after 12 weeks
Changes in electrolytes concentration following dietary intervention
Na+ (mg/dl), K+ (mg/dl), Cl- (mg/dl) and HCO3- (mg/dl) concentration analysis
Time frame: Baseline and after 12 weeks
Changes in physical activity
physical activity (MET-minutes/week) collect data by using questionnaires
This platform is for informational purposes only and does not constitute medical advice. Always consult a qualified healthcare professional.
Time frame: Baseline and after 12 weeks
Change from baseline Glycemia at 180 minutes
glucose (mg/dl)
Time frame: Minutes after intake of 75 g glucose: 0, 30, 60, 90, 120, 180
Change from baseline Insulin at 180 minutes
insulin (μU/ml)
Time frame: Minutes after intake of 75 g glucose: 0, 30, 60, 90, 120, 180
Changes in blood pressure
systolic and diastolic blood pressure (mmHg)
Time frame: Baseline and after 12 weeks
Changes in fasting leptin levels
leptin (mg/dl) concentration analysis
Time frame: Baseline and after 12 weeks
Changes in energy intake following dietary intervention
energy (kcal)
Time frame: Baseline and after 12 weeks
Changes in carbohydrate following dietary intervention
carbohydrate (g)
Time frame: Baseline and after 12 weeks
Changes in protein intake following dietary intervention
protein (g)
Time frame: Baseline and after 12 weeks
Changes in fat intake following dietary intervention
fat (g)
Time frame: Baseline and after 12 weeks