Urinary Creatinin/Protein Ratio in Preterms

Centre Hospitalier Universitaire de la Réunion124 enrolled

Overview

From the first days of life, the newborn presents a "physiological" proteinuria explained by the coexistence of a glomerular and tubular immaturity, all the more marked as the gestational age (GA) is weak. In the child term, proteinuria decreases the first month and its persistence is the marker of kidney damage. The persistence of proteinuria in preterm infants is also considered a marker of renal impairment; however, neither the "physiological" values nor the pattern of urinary excretion of proteins in the first month of life are known. The proteinuria / creatininuria ratio is a validated indicator of proteinuria, as it is correlated with 24-hour urine proteinuria.

Study Type

OBSERVATIONAL

Enrollment

124

Conditions

Preterm Infant Renal Failure

Eligibility

Sex: ALLMin age: 1 DayMax age: 2 Days

Medical Language ↔ Plain English

Inclusion Criteria: * Premature gestational age at birth superior or equal to 32 week of amenorrhea hospitalized in the intensive care unit or neonatal intensive care unit of the University Hospital of Reunion, southern site, Saint Pierre, in the first 24 hours of life * Informed consent form Legal representant Exclusion Criteria: * Renal malformation known in antenatal

Locations (1)

Outcomes

Primary Outcomes

Evolution in time of Ratio of proteinuria / creatininuria

Ratio of proteinuria / creatinine to P1 (D0), P2 (D2 or D3), P3 (D5 or D6), P4 (W2), P5 (W3) and P6 (W4).

Time frame: Day 0, Day 2 or Day 3, Day 5 or Day 6, Week 2, Week 3, Week 4