Comparative Analysis of the Effectiveness of the Use of Nimesulide and CBD Oil in Patients With Pain in the Preauricular Region Due to the Pain-dysfunctional Syndrome of the Temporomandibular Joint.

Inclusion Criteria: 1. Patients (female and male) aged 18-65 years, able to swallow tablets 2. Patients with pain located in the temporomandibular and preauricular regions resulting from temporomandibular joint dysfunction 3. Patients with clinical diagnosis of Temporomandibular Joint Dysfunction Exclusion Criteria: 1. patients with clinically diagnosed acute inflammation of the outer ear, middle ear, sinuses of the nose 2. patients allergic to nimesulide or cannabidiol oil 3. patients with contraindications to include therapy with nimesulide or cannabidiol oil such as: * gastric or duodenal ulcer disease, * severe blood clotting disorders, * severe liver dysfunction, * severe renal impairment, * severe heart failure, pregnancy, * breastfeeding, * concomitant intake of citrochrome blockers CYP3A4 or CYPP2D6 (warfarin, macrolides, calcium channel blockers, benzodiazepines, cyclosporine, sildenafil, SSRI, tricyclic antidepressants, opioids)